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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ftl H0K Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 1.184
4ftk H9KSerine/threonine-protein kinase Chk1 2.7.11.1 1.095
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 1.056
4ftn 2HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.914
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.854
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.853
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.755
3t9i 3T9Serine/threonine-protein kinase pim-1 2.7.11.1 0.730
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.728
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.718
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.716
4ftj H8KSerine/threonine-protein kinase Chk1 2.7.11.1 0.711
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.709
2e9n 76ASerine/threonine-protein kinase Chk1 2.7.11.1 0.702
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.698
2xm9 LWHSerine/threonine-protein kinase Chk2 2.7.11.1 0.689
4c35 NU3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.685
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.683
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.682
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.682
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.680
2e9o A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.679
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4fti H7KSerine/threonine-protein kinase Chk1 2.7.11.1 0.675
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.673
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.671
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.669
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.668
2ykj YKJHeat shock protein HSP 90-alpha / 0.666
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.663
4ftm 1HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.663
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.662
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.660
4fsz HK8Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
4jlc SU6Serine/threonine-protein kinase TBK1 2.7.11.1 0.658
4zth GG5Mitogen-activated protein kinase 14 / 0.657
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.652
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651