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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ftk H9K Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ftk H9KSerine/threonine-protein kinase Chk1 2.7.11.1 1.118
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 1.095
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 1.015
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.909
4ftn 2HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.886
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.779
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.768
3t9i 3T9Serine/threonine-protein kinase pim-1 2.7.11.1 0.725
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.711
2ayp 43ASerine/threonine-protein kinase Chk1 2.7.11.1 0.684
4e5l DBHPolymerase acidic protein / 0.675
2e9n 76ASerine/threonine-protein kinase Chk1 2.7.11.1 0.674
2xbj XBJSerine/threonine-protein kinase Chk2 2.7.11.1 0.674
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.668
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.668
3wix LC3Induced myeloid leukemia cell differentiation protein Mcl-1 / 0.667
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.665
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.657
4c35 NU3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.653
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.650