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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fsw HK6 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fsw HK6Serine/threonine-protein kinase Chk1 2.7.11.1 0.850
4ft0 HK9Serine/threonine-protein kinase Chk1 2.7.11.1 0.818
4ftr 5HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.817
4fsy HK7Serine/threonine-protein kinase Chk1 2.7.11.1 0.796
4gh2 HK0Serine/threonine-protein kinase Chk1 2.7.11.1 0.760
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.722
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.675
3vid 4TTVascular endothelial growth factor receptor 2 2.7.10.1 0.669
1y6a AAZVascular endothelial growth factor receptor 2 2.7.10.1 0.666
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.662
4e5f 0N7Polymerase acidic protein / 0.660
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
4jaj XU1Aurora kinase A 2.7.11.1 0.655