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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fsu HK5 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 1.065
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 1.059
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.967
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.964
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.952
4ftq 4HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.826
2e9o A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.798
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.776
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.746
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.732
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.698
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.694
2vag V25Dual specificity protein kinase CLK1 2.7.12.1 0.691
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.691
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.686
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.685
4c59 FEFCyclin-G-associated kinase 2.7.11.1 0.676
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.668
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.667
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.664
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.655
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2e9u A25Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.652
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.651
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.650
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.650
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650