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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fqs LYA Thymidylate synthase ThyA

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fqs LYAThymidylate synthase ThyA / 1.138
3k2h LYABifunctional dihydrofolate reductase-thymidylate synthase / 0.862
1jtu LYBThymidylate synthase / 0.835
3uwl FOZThymidylate synthase / 0.763
1ju6 LYAThymidylate synthase 2.1.1.45 0.745
4knz CB3Thymidylate synthase / 0.725
4gev CB3Thymidylate synthase / 0.724
1tys DHFThymidylate synthase / 0.707
4fog C2FThymidylate synthase ThyA / 0.703
2fto CB3Thymidylate synthase / 0.702
4o7u THFThymidylate synthase / 0.660
3bgx MEFThymidylate synthase / 0.654