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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fny I3K ALK tyrosine kinase receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fny I3KALK tyrosine kinase receptor 2.7.10.1 1.223
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.771
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.768
2qu5 276Vascular endothelial growth factor receptor 2 2.7.10.1 0.673
3b8q 900Vascular endothelial growth factor receptor 2 2.7.10.1 0.668
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.665
4btk DTQTau-tubulin kinase 1 2.7.11.1 0.658
4wkq IREEpidermal growth factor receptor 2.7.10.1 0.658
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.651