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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fkw 62K Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 1.039
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.963
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.900
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.886
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.873
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.872
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.855
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.842
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.832
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.831
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.825
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.815
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.814
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.813
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.780
1fvv 107Cyclin-dependent kinase 2 2.7.11.22 0.755
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.734
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.730
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.727
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.721
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.720
3say OFTGlycogen synthase kinase-3 beta 2.7.11.26 0.718
3mtl FEFCyclin-dependent kinase 16 2.7.11.22 0.708
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.706
3eb0 DRKUncharacterized protein / 0.705
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.703
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.702
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.702
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.698
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.697
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.692
4c59 FEFCyclin-G-associated kinase 2.7.11.1 0.684
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.681
4ftn 2HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.677
2r3m SCXCyclin-dependent kinase 2 2.7.11.22 0.676
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.676
1gij 2PUCyclin-dependent kinase 2 2.7.11.22 0.674
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.674
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.674
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.673
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.671
2c6o 4SPCyclin-dependent kinase 2 2.7.11.22 0.670
1unh IXMCyclin-dependent-like kinase 5 2.7.11.1 0.667
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.666
2c6i DT1Cyclin-dependent kinase 2 2.7.11.22 0.660
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.660
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.658
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.658
3r9h Z67Cyclin-dependent kinase 2 2.7.11.22 0.658
2r3k SCQCyclin-dependent kinase 2 2.7.11.22 0.655
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
3lpb NVBTyrosine-protein kinase JAK2 / 0.653
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.652