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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fks 46K Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fks 46KCyclin-dependent kinase 2 2.7.11.22 1.097
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.971
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.941
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.939
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.905
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.900
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.871
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.838
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.827
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.823
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.822
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.810
1fvv 107Cyclin-dependent kinase 2 2.7.11.22 0.806
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.801
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.801
3mtl FEFCyclin-dependent kinase 16 2.7.11.22 0.755
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.752
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.744
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.735
2bhe BRYCyclin-dependent kinase 2 2.7.11.22 0.732
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.724
3eb0 DRKUncharacterized protein / 0.710
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.705
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.704
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.701
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.700
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.697
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.692
3say OFTGlycogen synthase kinase-3 beta 2.7.11.26 0.691
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.690
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.690
1unh IXMCyclin-dependent-like kinase 5 2.7.11.1 0.687
2vto LZ8Cyclin-dependent kinase 2 2.7.11.22 0.686
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.684
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.682
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.680
3rpo 24ZCyclin-dependent kinase 2 2.7.11.22 0.679
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.678
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.677
3g0e B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.676
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.675
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.674
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.672
3r1y X76Cyclin-dependent kinase 2 2.7.11.22 0.671
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.668
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.668
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.668
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.667
1w0x OLOCyclin-dependent kinase 2 2.7.11.22 0.667
2r3r 6SCCyclin-dependent kinase 2 2.7.11.22 0.667
2c6l DT4Cyclin-dependent kinase 2 2.7.11.22 0.666
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.666
3r7e X88Cyclin-dependent kinase 2 2.7.11.22 0.665
3r7v Z02Cyclin-dependent kinase 2 2.7.11.22 0.665
1y8y CT7Cyclin-dependent kinase 2 2.7.11.22 0.664
3g0f B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.663
2r3j SCJCyclin-dependent kinase 2 2.7.11.22 0.662
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.662
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.661
3lpb NVBTyrosine-protein kinase JAK2 / 0.661
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.660
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.659
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.659
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.658
1pxl CK4Cyclin-dependent kinase 2 2.7.11.22 0.657
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.655
4aw5 30KEphrin type-B receptor 4 2.7.10.1 0.655
5ap7 SVEDual specificity protein kinase TTK 2.7.12.1 0.655
3r9d X6BCyclin-dependent kinase 2 2.7.11.22 0.653
3s1h 56ZCyclin-dependent kinase 2 2.7.11.22 0.653
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.653
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.651
4qmz B49Serine/threonine-protein kinase 24 2.7.11.1 0.651