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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fhb FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fhb FOLDihydrofolate reductase 1.5.1.3 0.998
4x5g FOLDihydrofolate reductase 1.5.1.3 0.904
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.897
4x5f FOLDihydrofolate reductase 1.5.1.3 0.887
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.872
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.860
1dyh DZFDihydrofolate reductase 1.5.1.3 0.858
4kjj FOLDihydrofolate reductase 1.5.1.3 0.845
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.839
7dfr FOLDihydrofolate reductase 1.5.1.3 0.836
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.831
1re7 FOLDihydrofolate reductase 1.5.1.3 0.823
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.818
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.812
1dyi FOLDihydrofolate reductase 1.5.1.3 0.804
3tqb FOLDihydrofolate reductase / 0.795
4m6k FOLDihydrofolate reductase 1.5.1.3 0.791
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.789
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.785
2zza FOLDihydrofolate reductase / 0.782
4i13 FOLDihydrofolate reductase 1.5.1.3 0.780
1drf FOLDihydrofolate reductase 1.5.1.3 0.779
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.776
1dyj DDFDihydrofolate reductase 1.5.1.3 0.765
4i1n FOLDihydrofolate reductase 1.5.1.3 0.761
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.751
1jom FFODihydrofolate reductase 1.5.1.3 0.750
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.750
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.746
4x5h FOLDihydrofolate reductase 1.5.1.3 0.745
2d0k FOLDihydrofolate reductase 1.5.1.3 0.743
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.739
1dhf FOLDihydrofolate reductase 1.5.1.3 0.738
3dau MTXDihydrofolate reductase 1.5.1.3 0.738
5ccc DDFDihydrofolate reductase 1.5.1.3 0.737
1hfq MOTDihydrofolate reductase 1.5.1.3 0.734
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.732
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.731
3frd DHFDihydrofolate reductase 1.5.1.3 0.728
4kfj FOLDihydrofolate reductase 1.5.1.3 0.726
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.722
3dfr MTXDihydrofolate reductase 1.5.1.3 0.721
2drc MTXDihydrofolate reductase 1.5.1.3 0.717
3ghw GHWDihydrofolate reductase 1.5.1.3 0.715
1hfr MOTDihydrofolate reductase 1.5.1.3 0.714
2qk8 MTXDihydrofolate reductase / 0.714
5hi6 MTXDihydrofolate reductase / 0.712
1dre MTXDihydrofolate reductase 1.5.1.3 0.709
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.706
3eig MTXDihydrofolate reductase 1.5.1.3 0.706
4qi9 MTXDihydrofolate reductase / 0.703
1jol FFODihydrofolate reductase 1.5.1.3 0.700
1ohj COPDihydrofolate reductase 1.5.1.3 0.700
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.700
1df7 MTXDihydrofolate reductase 1.5.1.3 0.698
1tdr MTXDihydrofolate reductase 1.5.1.3 0.697
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.695
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.692
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.689
1hfp MOTDihydrofolate reductase 1.5.1.3 0.685
1e26 GPBDihydrofolate reductase 1.5.1.3 0.683
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.683
2w3m FOLDihydrofolate reductase 1.5.1.3 0.683
4x5i FOLDihydrofolate reductase 1.5.1.3 0.683
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.682
3drc MTXDihydrofolate reductase 1.5.1.3 0.681
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.676
1dls MTXDihydrofolate reductase 1.5.1.3 0.676
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.676
4dfr MTXDihydrofolate reductase 1.5.1.3 0.676
4m6l 21VDihydrofolate reductase 1.5.1.3 0.675
1dhj MTXDihydrofolate reductase 1.5.1.3 0.673
3ghv GHCDihydrofolate reductase 1.5.1.3 0.672
4keb FOLDihydrofolate reductase 1.5.1.3 0.672
3och 2MXDihydrofolate reductase 1.5.1.3 0.671
1u72 MTXDihydrofolate reductase 1.5.1.3 0.670
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.670
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.668
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.660
3tq9 MTXDihydrofolate reductase / 0.659
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.658
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.657
1toi HCIAspartate aminotransferase 2.6.1.1 0.654
1u70 MTXDihydrofolate reductase 1.5.1.3 0.653
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.650
4ixf IXFDihydrofolate reductase 1.5.1.3 0.650