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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fco 0U4 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fco 0U4Beta-secretase 1 3.4.23.46 1.492
2b8l 5HABeta-secretase 1 3.4.23.46 1.313
2p8h MY9Beta-secretase 1 3.4.23.46 1.243
2vkm BSDBeta-secretase 1 3.4.23.46 1.161
2qzl IXSBeta-secretase 1 3.4.23.46 1.144
2b8v 3BNBeta-secretase 1 3.4.23.46 1.130
4gid 0GHBeta-secretase 1 3.4.23.46 1.087
2viz VG4Beta-secretase 1 3.4.23.46 1.072
3i25 MV7Beta-secretase 1 3.4.23.46 1.066
3ixj 586Beta-secretase 1 3.4.23.46 1.065
2xfj VG5Beta-secretase 1 3.4.23.46 1.052
2wf2 ZY2Beta-secretase 1 3.4.23.46 1.045
2vj6 VG5Beta-secretase 1 3.4.23.46 1.037
2xfk AA9Beta-secretase 1 3.4.23.46 1.037
2vnm CM8Beta-secretase 1 3.4.23.46 1.034
2vij C44Beta-secretase 1 3.4.23.46 1.032
2vj7 VG6Beta-secretase 1 3.4.23.46 1.028
2vj9 VG7Beta-secretase 1 3.4.23.46 1.025
2xfi XFIBeta-secretase 1 3.4.23.46 1.025
2wez ZYEBeta-secretase 1 3.4.23.46 1.011
2wf1 ZY1Beta-secretase 1 3.4.23.46 1.003
3dm6 757Beta-secretase 1 3.4.23.46 1.002
2wf0 ZY0Beta-secretase 1 3.4.23.46 1.001
2vnn CM7Beta-secretase 1 3.4.23.46 0.994
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.993
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.991
4dpf 0LGBeta-secretase 1 3.4.23.46 0.969
2viy VG3Beta-secretase 1 3.4.23.46 0.968
2p4j 23IBeta-secretase 1 3.4.23.46 0.918
2irz I02Beta-secretase 1 3.4.23.46 0.916
3ixk 929Beta-secretase 1 3.4.23.46 0.911
3tpr 5HABeta-secretase 1 3.4.23.46 0.905
3k5g BJCBeta-secretase 1 3.4.23.46 0.900
2iqg F2IBeta-secretase 1 3.4.23.46 0.889
3cib 314Beta-secretase 1 3.4.23.46 0.886
3lpj Z75Beta-secretase 1 3.4.23.46 0.886
3k5c 0BIBeta-secretase 1 3.4.23.46 0.883
4ewo 996Beta-secretase 1 3.4.23.46 0.878
4exg 916Beta-secretase 1 3.4.23.46 0.871
3cic 316Beta-secretase 1 3.4.23.46 0.869
3veu 0GOBeta-secretase 1 3.4.23.46 0.861
3ohh 3HHBeta-secretase 1 3.4.23.46 0.853
3ohf 3HFBeta-secretase 1 3.4.23.46 0.846
4k9h 1QUBeta-secretase 1 3.4.23.46 0.841
3dv5 BAVBeta-secretase 1 3.4.23.46 0.834
3lpk Z76Beta-secretase 1 3.4.23.46 0.818
3qi1 C6ABeta-secretase 1 3.4.23.46 0.812
3r2f PB0Beta-secretase 1 3.4.23.46 0.812
3nsh 957Beta-secretase 1 3.4.23.46 0.810
4i0i 957Beta-secretase 1 3.4.23.46 0.810
2p83 MR0Beta-secretase 1 3.4.23.46 0.803
2oah QINBeta-secretase 1 3.4.23.46 0.801
3cid 318Beta-secretase 1 3.4.23.46 0.794
4dh6 0KNBeta-secretase 1 3.4.23.46 0.787
3lpi Z74Beta-secretase 1 3.4.23.46 0.786
4ke0 1R8Beta-secretase 1 3.4.23.46 0.780
4lxa 1YSBeta-secretase 1 3.4.23.46 0.778
2ntr L00Beta-secretase 1 3.4.23.46 0.776
4lxk 1YTBeta-secretase 1 3.4.23.46 0.775
2ph6 712Beta-secretase 1 3.4.23.46 0.765
4i0h 1BLBeta-secretase 1 3.4.23.46 0.762
2vie VG0Beta-secretase 1 3.4.23.46 0.757
2hiz LIJBeta-secretase 1 3.4.23.46 0.749
3pi5 3P5Beta-secretase 1 3.4.23.46 0.748
3k5f AYHBeta-secretase 1 3.4.23.46 0.746
3qbh QBHBeta-secretase 1 3.4.23.46 0.742
4i0j 842Beta-secretase 1 3.4.23.46 0.741
2fdp FRPBeta-secretase 1 3.4.23.46 0.732
4dus 0MPBeta-secretase 1 3.4.23.46 0.724
3duy AFJBeta-secretase 1 3.4.23.46 0.715
2g94 ZPQBeta-secretase 1 3.4.23.46 0.713
1w51 L01Beta-secretase 1 3.4.23.46 0.702
2f3f AXFBeta-secretase 1 3.4.23.46 0.701
4dpi 0N1Beta-secretase 1 3.4.23.46 0.701
2jjj 0QSEndothiapepsin 3.4.23.22 0.700
1gvv 0GMEndothiapepsin 3.4.23.22 0.698
1tqf 32PBeta-secretase 1 3.4.23.46 0.697
3n4l 842Beta-secretase 1 3.4.23.46 0.696
3pww ROCEndothiapepsin 3.4.23.22 0.696
2is0 I03Beta-secretase 1 3.4.23.46 0.694
3k5d XLIBeta-secretase 1 3.4.23.46 0.690
1b6p PI7Gag-Pol polyprotein 3.4.23.16 0.686
4ke1 1R6Beta-secretase 1 3.4.23.46 0.677
3own 3OXRenin 3.4.23.15 0.675
2jji 0QSEndothiapepsin 3.4.23.22 0.671
4k8s 1QTBeta-secretase 1 3.4.23.46 0.671
1iiq 0ZRGag-Pol polyprotein 3.4.23.16 0.666
1psa 0ZLPepsin A 3.4.23.1 0.666
1w6h TITPlasmepsin-2 3.4.23.39 0.664
3oqf S51Renin 3.4.23.15 0.661
3vf3 0GSBeta-secretase 1 3.4.23.46 0.657
2hm1 LIQBeta-secretase 1 3.4.23.46 0.655