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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fc0 0T2 Serine/threonine-protein kinase B-raf 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 1.352
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.906
4ksp 1SUSerine/threonine-protein kinase B-raf 2.7.11.1 0.841
3hv4 L51Mitogen-activated protein kinase 14 / 0.754
3hv5 R24Mitogen-activated protein kinase 14 / 0.737
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.729
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.720
3uvp 048Mitogen-activated protein kinase 14 / 0.718
3d83 GK6Mitogen-activated protein kinase 14 / 0.712
3uvr 06FMitogen-activated protein kinase 14 / 0.705
3gcu R48Mitogen-activated protein kinase 14 / 0.697
3bv2 P38Mitogen-activated protein kinase 14 / 0.694
3bv3 P39Mitogen-activated protein kinase 14 / 0.693
3uvq FS8Mitogen-activated protein kinase 14 / 0.693
1ove 358Mitogen-activated protein kinase 14 / 0.685
1wbs LI2Mitogen-activated protein kinase 14 / 0.684
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.684
4aa0 AA0Mitogen-activated protein kinase 14 / 0.681
1wbt WBTMitogen-activated protein kinase 14 / 0.679
3gcv SS6Mitogen-activated protein kinase 14 / 0.673
2bak AQZMitogen-activated protein kinase 14 / 0.666
4a9y AQZMitogen-activated protein kinase 14 / 0.666
3e93 19BMitogen-activated protein kinase 14 / 0.659
3vnt 0JAVascular endothelial growth factor receptor 2 2.7.10.1 0.659
3vo3 0KFVascular endothelial growth factor receptor 2 2.7.10.1 0.659
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.657
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 0.656
2oiq STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.655
3nnw EDDMitogen-activated protein kinase 14 / 0.655
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.654
1wbv LI3Mitogen-activated protein kinase 14 / 0.652
4equ G6ISerine/threonine-protein kinase 10 2.7.11.1 0.650