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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f99 ADP Cell division cycle 7-related protein kinase 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.983
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.950
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.824
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.818
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.807
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.807
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.805
5dt3 ATPAurora kinase A 2.7.11.1 0.801
1mq4 ADPAurora kinase A 2.7.11.1 0.793
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.789
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.787
5dn3 ATPAurora kinase A 2.7.11.1 0.786
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.784
4qny ANPMitogen activated protein kinase, putative / 0.784
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.782
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.781
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.781
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.781
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.780
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.777
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.776
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.775
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.775
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.769
5ce3 ADPProtein kinase YopO / 0.769
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.767
4ceg ADPAurora kinase A 2.7.11.1 0.767
1cm8 ANPMitogen-activated protein kinase 12 / 0.766
4dee ADPAurora kinase A 2.7.11.1 0.766
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.764
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.764
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.763
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.762
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.762
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.760
4ysj ADPCalmodulin-like domain protein kinase / 0.758
3c50 ADPRhodopsin kinase / 0.754
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.753
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.752
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.752
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.750
4utd ACPAurora kinase A 2.7.11.1 0.750
3c4z ADPRhodopsin kinase / 0.749
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.749
5drd ATPAurora kinase A 2.7.11.1 0.749
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.746
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.745
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.744
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.742
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.741
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.741
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.738
4xlv ACPInsulin receptor 2.7.10.1 0.738
2olc ADPMethylthioribose kinase 2.7.1.100 0.737
3qc9 ADPRhodopsin kinase / 0.737
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.736
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.735
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.734
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.733
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.733
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.732
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.731
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.730
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.730
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
5dnr ATPAurora kinase A 2.7.11.1 0.730
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.729
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.728
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.728
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.727
5dos ATPAurora kinase A 2.7.11.1 0.727
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.726
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.725
3nie ANPMitogen-activated protein kinase / 0.724
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.723
2zdg ADPD-alanine--D-alanine ligase / 0.723
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.723
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.722
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.722
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.719
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.718
2pyw ADPMethylthioribose kinase 2.7.1.100 0.718
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.718
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.718
2pul ACPMethylthioribose kinase 2.7.1.100 0.716
3cly ACPFibroblast growth factor receptor 2 / 0.716
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.715
2pun ACPMethylthioribose kinase 2.7.1.100 0.715
4bn1 ADPAurora kinase A 2.7.11.1 0.715
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.714
2pui ADPMethylthioribose kinase 2.7.1.100 0.714
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.713
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.713
2pml ANPUncharacterized protein / 0.712
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.712
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.712
2pup ADPMethylthioribose kinase 2.7.1.100 0.711
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.711
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.711
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.710
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.709
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.707
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.706
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.706
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.706
3rv4 ADPBiotin carboxylase 6.3.4.14 0.705
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.705
1ol5 ADPAurora kinase A 2.7.11.1 0.704
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.704
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.703
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.703
4gyi ADPUncharacterized protein / 0.703
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.703
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.701
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.696
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.696
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.696
5dt4 ATPAurora kinase A 2.7.11.1 0.696
1ol6 ATPAurora kinase A 2.7.11.1 0.695
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.695
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.694
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.694
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.694
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.693
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.693
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.691
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.691
3t8o ATPRhodopsin kinase / 0.691
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.691
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
3q5i ANPProtein kinase, putative / 0.690
4o1p ANPRibonuclease L / 0.690
4ffl ADPUncharacterized protein / 0.688
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.688
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.687
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.687
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.685
4ork GDPBifunctional AAC/APH 2.3.1 0.685
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.684
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.684
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.683
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.683
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.683
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.683
4ix5 ANPUncharacterized protein / 0.683
4o4f ATPKinase / 0.683
4c3r ACPAurora kinase A 2.7.11.1 0.682
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.681
5dr2 ATPAurora kinase A 2.7.11.1 0.681
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.680
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.680
5eg3 ACPFibroblast growth factor receptor 2 / 0.680
4q5h ANPProtein kinase OspG 2.7 0.679
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.678
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.677
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
3g8c ADPBiotin carboxylase 6.3.4.14 0.677
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.676
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.676
3wnz ADPAlanine--anticapsin ligase / 0.676
1m0w ANPGlutathione synthetase 6.3.2.3 0.674
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.674
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.673
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.673
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.672
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.672
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.671
3wo1 ADPAlanine--anticapsin ligase / 0.670
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.670
4ffm ADPUncharacterized protein / 0.670
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.669
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.668
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.668
3tw6 ADPPyruvate carboxylase / 0.668
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.667
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.667
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.665
3bu5 ATPInsulin receptor 2.7.10.1 0.665
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.665
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.664
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.664
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.663
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.663
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.663
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3a8w ATPProtein kinase C iota type 2.7.11.13 0.662
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.662
5iqb GNPBifunctional AAC/APH 2.3.1 0.662
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.661
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.661
4lrj ANPUncharacterized protein / 0.661
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.660
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.660
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.659
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.659
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.659
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.659
5iqg GDPBifunctional AAC/APH 2.3.1 0.659
2vqd AP2Biotin carboxylase 6.3.4.14 0.657
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
5iqd GNPBifunctional AAC/APH 2.3.1 0.657
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.656
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.656
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.655
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.655
3d5w ADPSerine/threonine-protein kinase PLK / 0.655
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.655
1pk8 ATPSynapsin-1 / 0.654
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.654
2wqe ADPAurora kinase A 2.7.11.1 0.653
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.653
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.653
5l8j ADPAurora kinase A 2.7.11.1 0.653
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.652
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.652
1mbz IOTCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.651
3oii SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.651
4cnf MTASpoU rRNA methylase / 0.651
5c93 ACPTwo-component system histidine protein kinase / 0.651
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.650
2dwb ANPAurora kinase A 2.7.11.1 0.650
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.650
3g8d ADPBiotin carboxylase 6.3.4.14 0.650
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.650
5byl GCPBifunctional AAC/APH 2.3.1 0.650