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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f7n 0SV Cyclin-dependent kinase 8 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 1.192
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.892
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.853
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.834
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.830
3hv6 R39Mitogen-activated protein kinase 14 / 0.792
2yiw YIWMitogen-activated protein kinase 14 / 0.787
3lfb Z87Mitogen-activated protein kinase 14 / 0.784
1w82 L10Mitogen-activated protein kinase 14 / 0.779
2puu G2GMitogen-activated protein kinase 14 / 0.768
3nnw EDDMitogen-activated protein kinase 14 / 0.768
3hv3 R49Mitogen-activated protein kinase 14 / 0.766
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.766
3hv4 L51Mitogen-activated protein kinase 14 / 0.759
3uvr 06FMitogen-activated protein kinase 14 / 0.754
3pg3 DG7Mitogen-activated protein kinase 14 / 0.750
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.748
2yis YISMitogen-activated protein kinase 14 / 0.747
3hv5 R24Mitogen-activated protein kinase 14 / 0.746
3nnx EDDMitogen-activated protein kinase 14 / 0.742
3gcq 1BUMitogen-activated protein kinase 14 / 0.739
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.732
3gcu R48Mitogen-activated protein kinase 14 / 0.729
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.725
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.724
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.720
1kv2 B96Mitogen-activated protein kinase 14 / 0.700
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.694
3gi3 B10Mitogen-activated protein kinase 14 / 0.690
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.688
3o8t BMUMitogen-activated protein kinase 14 / 0.685
3oc1 BMUMitogen-activated protein kinase 14 / 0.684
3o8u BMUMitogen-activated protein kinase 14 / 0.682
3lff Z83Mitogen-activated protein kinase 14 / 0.680
3hv7 1AUMitogen-activated protein kinase 14 / 0.677
1kv1 BMUMitogen-activated protein kinase 14 / 0.675
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.672
3lfe Z84Mitogen-activated protein kinase 14 / 0.671
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.670
3nnu EDBMitogen-activated protein kinase 14 / 0.667
3p5k P5KMitogen-activated protein kinase 14 / 0.664
3e93 19BMitogen-activated protein kinase 14 / 0.663
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.655
3p7b P7BMitogen-activated protein kinase 14 / 0.653
3p7a P7AMitogen-activated protein kinase 14 / 0.652
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.651
3p79 P79Mitogen-activated protein kinase 14 / 0.650
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.650