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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f7l 0SO Cyclin-dependent kinase 8 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 1.140
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.871
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.834
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.820
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.770
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.770
3hv6 R39Mitogen-activated protein kinase 14 / 0.767
2puu G2GMitogen-activated protein kinase 14 / 0.754
2yiw YIWMitogen-activated protein kinase 14 / 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3lff Z83Mitogen-activated protein kinase 14 / 0.737
2yis YISMitogen-activated protein kinase 14 / 0.729
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.714
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.712
3lfb Z87Mitogen-activated protein kinase 14 / 0.707
3hv5 R24Mitogen-activated protein kinase 14 / 0.700
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.698
3hv7 1AUMitogen-activated protein kinase 14 / 0.690
3nnw EDDMitogen-activated protein kinase 14 / 0.685
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.684
3hv4 L51Mitogen-activated protein kinase 14 / 0.683
3hv3 R49Mitogen-activated protein kinase 14 / 0.681
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.679
1w82 L10Mitogen-activated protein kinase 14 / 0.664
3oc1 BMUMitogen-activated protein kinase 14 / 0.664
3nnu EDBMitogen-activated protein kinase 14 / 0.663
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.663
3nnx EDDMitogen-activated protein kinase 14 / 0.662
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.662
4e5f 0N7Polymerase acidic protein / 0.660
3gcq 1BUMitogen-activated protein kinase 14 / 0.657
3o8u BMUMitogen-activated protein kinase 14 / 0.656
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.654
3gcu R48Mitogen-activated protein kinase 14 / 0.650