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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f7j 0SU Cyclin-dependent kinase 8 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 1.073
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.896
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.895
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.830
3hv3 R49Mitogen-activated protein kinase 14 / 0.794
3hv6 R39Mitogen-activated protein kinase 14 / 0.790
3hv7 1AUMitogen-activated protein kinase 14 / 0.788
3hv4 L51Mitogen-activated protein kinase 14 / 0.785
1w82 L10Mitogen-activated protein kinase 14 / 0.780
2yiw YIWMitogen-activated protein kinase 14 / 0.775
3lff Z83Mitogen-activated protein kinase 14 / 0.772
3uvr 06FMitogen-activated protein kinase 14 / 0.772
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.770
3hv5 R24Mitogen-activated protein kinase 14 / 0.767
3lfb Z87Mitogen-activated protein kinase 14 / 0.767
2yis YISMitogen-activated protein kinase 14 / 0.766
2puu G2GMitogen-activated protein kinase 14 / 0.756
3gcq 1BUMitogen-activated protein kinase 14 / 0.756
3gcu R48Mitogen-activated protein kinase 14 / 0.746
3nnx EDDMitogen-activated protein kinase 14 / 0.742
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.741
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.739
3pg3 DG7Mitogen-activated protein kinase 14 / 0.737
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.737
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.731
3lfe Z84Mitogen-activated protein kinase 14 / 0.725
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.714
3o8t BMUMitogen-activated protein kinase 14 / 0.703
1kv2 B96Mitogen-activated protein kinase 14 / 0.693
1kv1 BMUMitogen-activated protein kinase 14 / 0.690
3lfc Z86Mitogen-activated protein kinase 14 / 0.689
3p5k P5KMitogen-activated protein kinase 14 / 0.688
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.686
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.683
3o8u BMUMitogen-activated protein kinase 14 / 0.680
3p7b P7BMitogen-activated protein kinase 14 / 0.679
3p7c P7CMitogen-activated protein kinase 14 / 0.679
3oc1 BMUMitogen-activated protein kinase 14 / 0.672
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.669
3nnu EDBMitogen-activated protein kinase 14 / 0.667
3nnw EDDMitogen-activated protein kinase 14 / 0.658
3gi3 B10Mitogen-activated protein kinase 14 / 0.653
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.651
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.650