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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f6w 0SS Cyclin-dependent kinase 8 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 1.329
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.902
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.896
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.853
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.820
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.801
2yiw YIWMitogen-activated protein kinase 14 / 0.791
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.789
3hv3 R49Mitogen-activated protein kinase 14 / 0.779
1w82 L10Mitogen-activated protein kinase 14 / 0.775
3lff Z83Mitogen-activated protein kinase 14 / 0.774
2yis YISMitogen-activated protein kinase 14 / 0.756
3hv6 R39Mitogen-activated protein kinase 14 / 0.756
3uvr 06FMitogen-activated protein kinase 14 / 0.736
3gcq 1BUMitogen-activated protein kinase 14 / 0.735
3gcv SS6Mitogen-activated protein kinase 14 / 0.731
3hv4 L51Mitogen-activated protein kinase 14 / 0.731
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.729
3lfe Z84Mitogen-activated protein kinase 14 / 0.727
3hv7 1AUMitogen-activated protein kinase 14 / 0.725
3nnx EDDMitogen-activated protein kinase 14 / 0.713
3pg3 DG7Mitogen-activated protein kinase 14 / 0.709
2puu G2GMitogen-activated protein kinase 14 / 0.707
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.705
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.705
3lfb Z87Mitogen-activated protein kinase 14 / 0.704
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.702
3o8u BMUMitogen-activated protein kinase 14 / 0.698
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.698
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.696
1kv2 B96Mitogen-activated protein kinase 14 / 0.692
3gcu R48Mitogen-activated protein kinase 14 / 0.684
3nnw EDDMitogen-activated protein kinase 14 / 0.683
1kv1 BMUMitogen-activated protein kinase 14 / 0.673
3hv5 R24Mitogen-activated protein kinase 14 / 0.673
3p5k P5KMitogen-activated protein kinase 14 / 0.668
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.667
3gi3 B10Mitogen-activated protein kinase 14 / 0.662
3p79 P79Mitogen-activated protein kinase 14 / 0.661
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.656
3o8t BMUMitogen-activated protein kinase 14 / 0.655
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.654
3p7c P7CMitogen-activated protein kinase 14 / 0.654
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.651