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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f6s 0SQ Cyclin-dependent kinase 8 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 1.008
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.902
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.895
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.892
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.871
3hv3 R49Mitogen-activated protein kinase 14 / 0.788
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.782
2puu G2GMitogen-activated protein kinase 14 / 0.777
2yis YISMitogen-activated protein kinase 14 / 0.764
3hv5 R24Mitogen-activated protein kinase 14 / 0.758
2yiw YIWMitogen-activated protein kinase 14 / 0.755
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3nnw EDDMitogen-activated protein kinase 14 / 0.743
3hv7 1AUMitogen-activated protein kinase 14 / 0.740
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.729
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.728
3gcu R48Mitogen-activated protein kinase 14 / 0.725
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.721
3hv4 L51Mitogen-activated protein kinase 14 / 0.720
3lfb Z87Mitogen-activated protein kinase 14 / 0.719
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.714
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.713
1w82 L10Mitogen-activated protein kinase 14 / 0.702
3lfe Z84Mitogen-activated protein kinase 14 / 0.697
3o8u BMUMitogen-activated protein kinase 14 / 0.696
3pg3 DG7Mitogen-activated protein kinase 14 / 0.696
3uvr 06FMitogen-activated protein kinase 14 / 0.691
1kv1 BMUMitogen-activated protein kinase 14 / 0.690
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.690
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.689
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.687
3nnx EDDMitogen-activated protein kinase 14 / 0.684
3gcq 1BUMitogen-activated protein kinase 14 / 0.682
3lff Z83Mitogen-activated protein kinase 14 / 0.682
3hv6 R39Mitogen-activated protein kinase 14 / 0.679
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.678
3oc1 BMUMitogen-activated protein kinase 14 / 0.673
3p5k P5KMitogen-activated protein kinase 14 / 0.673
3o8t BMUMitogen-activated protein kinase 14 / 0.668
3p7c P7CMitogen-activated protein kinase 14 / 0.665
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.662
4e5f 0N7Polymerase acidic protein / 0.660
3p7b P7BMitogen-activated protein kinase 14 / 0.657
3p79 P79Mitogen-activated protein kinase 14 / 0.653