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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f1m ACP Probable serine/threonine-protein kinase roco4 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.795
4f0f ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.719
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.714
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.687
4f1o ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.687
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.682
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.681
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.678
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.673
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.670
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.669
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.667
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.666
2pup ADPMethylthioribose kinase 2.7.1.100 0.665
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.665
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.664
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.664
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.664
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.663
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.660
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.658
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.657
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.656
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.656
1ol6 ATPAurora kinase A 2.7.11.1 0.655
3d5w ADPSerine/threonine-protein kinase PLK / 0.655
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.655
2wqe ADPAurora kinase A 2.7.11.1 0.654
4jrn ANPRhoptry kinase family protein / 0.654
4q5h ANPProtein kinase OspG 2.7 0.654
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.653
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.653
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.652
3c50 ADPRhodopsin kinase / 0.652
3qc9 ADPRhodopsin kinase / 0.652
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.652
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.652
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.651
3c4z ADPRhodopsin kinase / 0.651
4c2w ANPAurora kinase B-A 2.7.11.1 0.651
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.650
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.650
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.650
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.650