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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ez8 DHF Thymidylate synthase 2.1.1.45

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ez8 DHFThymidylate synthase 2.1.1.45 0.974
2aaz CB3Thymidylate synthase 2.1.1.45 0.761
4eil CB3Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.759
1tys DHFThymidylate synthase / 0.747
2fto CB3Thymidylate synthase / 0.714
1jtq LY3Thymidylate synthase / 0.700
2tsc CB3Thymidylate synthase / 0.697
2bbq PFGThymidylate synthase / 0.696
4knz CB3Thymidylate synthase / 0.689
4gev CB3Thymidylate synthase / 0.687
1trg CB3Thymidylate synthase / 0.678
1hvy D16Thymidylate synthase 2.1.1.45 0.661