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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eyj N61 Mitogen-activated protein kinase 13 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 1.111
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.777
3uvr 06FMitogen-activated protein kinase 14 / 0.762
3o8u BMUMitogen-activated protein kinase 14 / 0.759
4eym 0RXMitogen-activated protein kinase 13 2.7.11.24 0.745
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.738
3lfe Z84Mitogen-activated protein kinase 14 / 0.733
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.733
3lfb Z87Mitogen-activated protein kinase 14 / 0.731
2yis YISMitogen-activated protein kinase 14 / 0.729
3p5k P5KMitogen-activated protein kinase 14 / 0.724
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.716
3p7b P7BMitogen-activated protein kinase 14 / 0.712
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.708
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.708
3hv6 R39Mitogen-activated protein kinase 14 / 0.698
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.694
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.690
3gcv SS6Mitogen-activated protein kinase 14 / 0.685
1kv1 BMUMitogen-activated protein kinase 14 / 0.684
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.682
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.682
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.682
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.682
3gi3 B10Mitogen-activated protein kinase 14 / 0.681
1kv2 B96Mitogen-activated protein kinase 14 / 0.679
3o8t BMUMitogen-activated protein kinase 14 / 0.678
3gcs BAXMitogen-activated protein kinase 14 / 0.677
3hv4 L51Mitogen-activated protein kinase 14 / 0.676
3ugc 046Tyrosine-protein kinase JAK2 / 0.673
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.673
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.668
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.667
2puu G2GMitogen-activated protein kinase 14 / 0.666
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.666
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.664
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.663
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.661
3gcu R48Mitogen-activated protein kinase 14 / 0.656
3pg3 DG7Mitogen-activated protein kinase 14 / 0.652
3hv5 R24Mitogen-activated protein kinase 14 / 0.651
3nnw EDDMitogen-activated protein kinase 14 / 0.650