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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eut BX7 Serine/threonine-protein kinase TBK1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.955
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.705
4im2 BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.702
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.690
2x81 ZZLAurora kinase A 2.7.11.1 0.685
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.681
2np8 CC3Aurora kinase A 2.7.11.1 0.677
3uo5 0BXAurora kinase A 2.7.11.1 0.677
3et7 349Protein-tyrosine kinase 2-beta 2.7.10.2 0.664
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1oec AA2Fibroblast growth factor receptor 2 / 0.659
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.658
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.658
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.658
4ftu 7HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.658
3h3c P1EProtein-tyrosine kinase 2-beta 2.7.10.2 0.657
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.654
2x6d X6DAurora kinase A 2.7.11.1 0.654
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.650