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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eue NAI Trans-2-enoyl-CoA reductase [NADH]

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4eue NAITrans-2-enoyl-CoA reductase [NADH] / 1.175
4bkq NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.969
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.915
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.812
4euf NADTrans-2-enoyl-CoA reductase [NADH] / 0.765
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.759
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.749
1vrw NAIEnoyl-ACP reductase / 0.746
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.744
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.744
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.740
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.737
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.731
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.719
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.717
3ai3 NDPNADPH-sorbose reductase / 0.716
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.709
3uce NDPDehydrogenase / 0.708
4yag NAIC alpha-dehydrogenase / 0.708
4yai NAIC alpha-dehydrogenase / 0.708
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.707
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.704
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.703
4b79 NADProbable short-chain dehydrogenase / 0.702
3p19 NDPPutative blue fluorescent protein / 0.698
1oaa NAPSepiapterin reductase 1.1.1.153 0.697
2dte NAIGlucose 1-dehydrogenase related protein / 0.696
1x7g NAPPutative ketoacyl reductase 1.3.1 0.693
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.692
4bmv NAPShort-chain dehydrogenase / 0.692
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.692
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.688
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.688
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.688
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.687
2yy7 NADL-threonine dehydrogenase / 0.686
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.685
2yut NAPPutative short-chain oxidoreductase / 0.684
4kwh NAPReductase homolog / 0.684
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.683
1g1a NADdTDP-glucose 4,6-dehydratase / 0.679
3ai2 NDPNADPH-sorbose reductase / 0.678
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.676
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.676
1x7h NDPPutative ketoacyl reductase 1.3.1 0.676
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.675
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.673
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.673
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.672
1v35 NAIEnoyl-ACP reductase / 0.671
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.671
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.669
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.669
3t4e NADQuinate/shikimate dehydrogenase / 0.669
1w4z NAPPutative ketoacyl reductase 1.3.1 0.668
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.668
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.667
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.667
2c29 NAPDihydroflavonol 4-reductase / 0.666
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.666
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.666
2wsb NADGalactitol dehydrogenase / 0.665
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.665
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.664
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.664
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.664
4o1m NADEnoyl-acyl carrier reductase / 0.662
5jla NADPutative short-chain dehydrogenase/reductase / 0.662
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.661
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.661
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.660
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.659
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.659
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.659
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.658
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.658
3iup NDPPossible NADH oxidoreductase / 0.658
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.658
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.657
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.656
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.656
4dbz NDPPutative ketoacyl reductase 1.3.1 0.656
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.656
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.655
4aic NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.655
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.655
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.654
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.654
3geg NADShort-chain dehydrogenase/reductase SDR / 0.654
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.654
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.653
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.653
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.652
3rud NADUDP-N-acetylglucosamine 4-epimerase / 0.651
4qed NAPElxO / 0.651
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.650
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.650