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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4elg 52J Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4elg 52JDihydrofolate reductase / 1.297
3fl8 RARDihydrofolate reductase / 1.102
4elb 34SDihydrofolate reductase / 0.856
3m08 RARDihydrofolate reductase 1.5.1.3 0.849
4elf 35IDihydrofolate reductase / 0.822
4ele 31IDihydrofolate reductase / 0.810
3m09 RARDihydrofolate reductase 1.5.1.3 0.795
4fgh 0U6Dihydrofolate reductase 1.5.1.3 0.732
3fl9 TOPDihydrofolate reductase / 0.716
2w3v TOPDihydrofolate reductase / 0.685
4fgg 0U5Dihydrofolate reductase 1.5.1.3 0.673
3dat MTXDihydrofolate reductase / 0.666
3l1s Z92Glycogen synthase kinase-3 beta 2.7.11.26 0.664
4elh 53IDihydrofolate reductase / 0.662
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
1m2r MNYCasein kinase II subunit alpha 2.7.11.1 0.657
1dra MTXDihydrofolate reductase 1.5.1.3 0.655
4qjq OTRLactoperoxidase / 0.650