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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ele 31I Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ele 31IDihydrofolate reductase / 1.113
4elf 35IDihydrofolate reductase / 0.983
3fl8 RARDihydrofolate reductase / 0.951
4elb 34SDihydrofolate reductase / 0.843
4elh 53IDihydrofolate reductase / 0.843
3m09 RARDihydrofolate reductase 1.5.1.3 0.822
3m08 RARDihydrofolate reductase 1.5.1.3 0.811
4elg 52JDihydrofolate reductase / 0.810
4elb 34RDihydrofolate reductase / 0.738
4fgg 0U5Dihydrofolate reductase 1.5.1.3 0.738
4fgh 0U6Dihydrofolate reductase 1.5.1.3 0.696
3frf XCFDihydrofolate reductase 1.5.1.3 0.693
3sqy Q11Dihydrofolate reductase 1.5.1.3 0.681
3fre TOPDihydrofolate reductase 1.5.1.3 0.661
3fy8 XCFDihydrofolate reductase 1.5.1.3 0.661
1dra MTXDihydrofolate reductase 1.5.1.3 0.654
2drc MTXDihydrofolate reductase 1.5.1.3 0.652
1tdr MTXDihydrofolate reductase 1.5.1.3 0.650