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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4elb 34S Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4elb 34SDihydrofolate reductase / 1.258
3fl8 RARDihydrofolate reductase / 0.898
4elg 52JDihydrofolate reductase / 0.856
4ele 31IDihydrofolate reductase / 0.843
4elf 35IDihydrofolate reductase / 0.800
4fgg 0U5Dihydrofolate reductase 1.5.1.3 0.714
3fl9 TOPDihydrofolate reductase / 0.713
3fyw XCFDihydrofolate reductase 1.5.1.3 0.705
3jw5 TOPDihydrofolate reductase / 0.705
4elh 53IDihydrofolate reductase / 0.697
2w9h TOPDihydrofolate reductase 1.5.1.3 0.690
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.684
4elb 34RDihydrofolate reductase / 0.681
1dyr TOPDihydrofolate reductase 1.5.1.3 0.680
3fre TOPDihydrofolate reductase 1.5.1.3 0.678
3sru Q26Dihydrofolate reductase 1.5.1.3 0.672
2drc MTXDihydrofolate reductase 1.5.1.3 0.669
2w9g TOPDihydrofolate reductase 1.5.1.3 0.668
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
3fyv XCFDihydrofolate reductase 1.5.1.3 0.653
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
3srs M23Dihydrofolate reductase 1.5.1.3 0.650
3tky N7I(Iso)eugenol O-methyltransferase 2.1.1.146 0.650