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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4egi B2J Heat shock protein HSP 90-alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4egi B2JHeat shock protein HSP 90-alpha / 0.778
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2wi2 ZZ3Heat shock protein HSP 90-alpha / 0.728
2yej ZZ3Heat shock protein HSP 90-alpha / 0.709
3ft5 MO8Heat shock protein HSP 90-alpha / 0.703
2qg0 A94Heat shock protein HSP 90-alpha / 0.675
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.666
3b2t M33Fibroblast growth factor receptor 2 / 0.666
2wi5 ZZ5Heat shock protein HSP 90-alpha / 0.663
4dt8 ADNAPH(2'')-Id / 0.663
1h7u AGSMismatch repair endonuclease PMS2 3.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.659
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.659
3r4n FU5Heat shock protein HSP 90-alpha / 0.657
2qg2 A91Heat shock protein HSP 90-alpha / 0.656
3rlp 3RPHeat shock protein HSP 90-alpha / 0.655
2ydi YDISerine/threonine-protein kinase Chk1 2.7.11.1 0.652
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.650
3rlq 3RQHeat shock protein HSP 90-alpha / 0.650