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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e2x TYD Methyltransferase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e2x TYDMethyltransferase / 1.078
4e2z JHZMethyltransferase / 1.028
3ndj JHZMethyltransferase / 1.026
4e2w JHZMethyltransferase / 1.010
4e31 JHZMethyltransferase / 1.008
4e32 DWNMethyltransferase / 1.006
4e2y JHZMethyltransferase / 0.989
4l9w GNPGTPase HRas / 0.675
3rs0 GNPGTPase HRas / 0.674
3rs4 GNPGTPase HRas / 0.674
3rs7 GNPGTPase HRas / 0.674
2rgg GNPGTPase HRas / 0.666
2bme GNPRas-related protein Rab-4A / 0.660
3i3s GNPGTPase HRas / 0.657
4kvg GTPRas-related protein Rap-1A / 0.657
1ky2 GNPGTP-binding protein YPT7 / 0.656
3oiu GNPGTPase HRas / 0.656
4g0n GNPGTPase HRas / 0.656
4xoi GTPTransforming protein RhoA / 0.654
1ayl ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.652
1tj2 FADBifunctional protein PutA 1.5.5.2 0.650