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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e20 0MY Non-receptor tyrosine-protein kinase TYK2 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e20 0MYNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 1.094
4e1z 0MXNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.879
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
4ftr 5HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.661
3w16 P9JAurora kinase A 2.7.11.1 0.660
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.655