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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e1z 0MX Non-receptor tyrosine-protein kinase TYK2 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e1z 0MXNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 1.064
4e20 0MYNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.879
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.668
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.665
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.658
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.653
3kkv B99cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650