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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4drm 0MC Peptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4drm 0MCPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 1.143
4dro 0MDPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.992
4drn 0MCPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.969
4drp 0MDPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.955
4drk I63Peptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.916
4lay I63Peptidyl-prolyl cis-trans isomerase FKBP4 5.2.1.8 0.862
4dh0 MR8Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.815
1fkg SB3Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.813
4jfi 1KTPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.806
4dz2 FK5Peptidyl-prolyl cis-trans isomerase / 0.768
1bl4 AP1Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.765
1tco FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.747
1tco FK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 3.1.3.16 0.747
2dg9 RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.747
1fkj FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.739
1fkh SBXPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.731
4odo FK5Peptidyl-prolyl cis-trans isomerase / 0.725
1bkf FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.720
2fke FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.712
2vn1 FK5Peptidylprolyl isomerase / 0.704
1c9h RAPPeptidyl-prolyl cis-trans isomerase FKBP1B 5.2.1.8 0.698
1fki SB1Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.690
1fkf FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.673
2dg3 RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.672
4qt3 RAPPeptidylprolyl isomerase / 0.670
1fkb RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.668
1a7x FKAPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.664
1fkd 818Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.664
3o5r FK5Peptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.664
1qpl 587Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.660
1fkl RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.654
2dg4 RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.650