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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dpl NAP Malonyl-CoA reductase 1.2.1.75

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dpl NAPMalonyl-CoA reductase 1.2.1.75 1.081
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.763
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.739
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.723
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.718
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.709
2rcy NAPPyrroline-5-carboxylate reductase / 0.685
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.683
3f3s NADLambda-crystallin homolog / 0.677
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.676
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.676
2i3g NAPN-acetyl-gamma-glutamyl-phosphate reductase 1.2.1.38 0.673
3hwr NDP2-dehydropantoate 2-reductase / 0.673
4dpm COAMalonyl-CoA reductase 1.2.1.75 0.673
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.672
4xgi NADGlutamate dehydrogenase / 0.672
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.671
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.670
3anm NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.669
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.665
1jn0 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.664
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.663
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.662
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.661
1gl3 NDPAspartate-semialdehyde dehydrogenase / 0.659
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.659
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.659
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.658
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.657
2czc NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.59 0.656
4y0k NAPAntE / 0.656
3tri NAPPyrroline-5-carboxylate reductase / 0.655
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.655
1lj8 NADMannitol dehydrogenase / 0.654
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.652
1rm5 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.652
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.652
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.652
1nqo NADGlyceraldehyde-3-phosphate dehydrogenase / 0.651
4xb2 NDP319aa long hypothetical homoserine dehydrogenase / 0.651
1qxs NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.650
4k28 NADShikimate dehydrogenase family protein / 0.650