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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dph P65 Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dph P65Bifunctional dihydrofolate reductase-thymidylate synthase / 1.014
4dp3 MMVBifunctional dihydrofolate reductase-thymidylate synthase / 0.731
1pd8 CO4Dihydrofolate reductase 1.5.1.3 0.728
1ly3 COGDihydrofolate reductase 1.5.1.3 0.716
1kms LIHDihydrofolate reductase 1.5.1.3 0.672
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.666
1boz PRDDihydrofolate reductase 1.5.1.3 0.665
1s3w TQTDihydrofolate reductase 1.5.1.3 0.662
3sgy 06WDihydrofolate reductase 1.5.1.3 0.661
3jsu KA5Bifunctional dihydrofolate reductase-thymidylate synthase / 0.657
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.656
1dds MTXDihydrofolate reductase 1.5.1.3 0.652
1hfr MOTDihydrofolate reductase 1.5.1.3 0.652
4p68 MTXDihydrofolate reductase / 0.652