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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dpd DHF Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.979
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.770
4kjj FOLDihydrofolate reductase 1.5.1.3 0.766
4kfj FOLDihydrofolate reductase 1.5.1.3 0.746
2d0k FOLDihydrofolate reductase 1.5.1.3 0.742
3ia4 MTXDihydrofolate reductase / 0.740
4m6l 21VDihydrofolate reductase 1.5.1.3 0.725
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.718
2zza FOLDihydrofolate reductase / 0.718
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.710
1df7 MTXDihydrofolate reductase 1.5.1.3 0.709
1e26 GPBDihydrofolate reductase 1.5.1.3 0.709
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.707
5ccc DDFDihydrofolate reductase 1.5.1.3 0.707
1dyj DDFDihydrofolate reductase 1.5.1.3 0.706
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.706
4keb FOLDihydrofolate reductase 1.5.1.3 0.703
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.702
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.701
1dls MTXDihydrofolate reductase 1.5.1.3 0.696
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.696
4x5f FOLDihydrofolate reductase 1.5.1.3 0.696
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.695
4p66 MTXDihydrofolate reductase / 0.692
4x5h FOLDihydrofolate reductase 1.5.1.3 0.692
1hfr MOTDihydrofolate reductase 1.5.1.3 0.690
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.690
4qi9 MTXDihydrofolate reductase / 0.689
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.688
1dyh DZFDihydrofolate reductase 1.5.1.3 0.686
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.686
5hi6 MTXDihydrofolate reductase / 0.686
3dfr MTXDihydrofolate reductase 1.5.1.3 0.685
3eig MTXDihydrofolate reductase 1.5.1.3 0.685
3tqb FOLDihydrofolate reductase / 0.685
4x5g FOLDihydrofolate reductase 1.5.1.3 0.683
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.676
7dfr FOLDihydrofolate reductase 1.5.1.3 0.676
1hfq MOTDihydrofolate reductase 1.5.1.3 0.675
3och 2MXDihydrofolate reductase 1.5.1.3 0.675
1drb MTXDihydrofolate reductase 1.5.1.3 0.674
2qk8 MTXDihydrofolate reductase / 0.674
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.674
1dra MTXDihydrofolate reductase 1.5.1.3 0.673
1hfp MOTDihydrofolate reductase 1.5.1.3 0.673
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.673
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.672
2drc MTXDihydrofolate reductase 1.5.1.3 0.672
3drc MTXDihydrofolate reductase 1.5.1.3 0.672
1re7 FOLDihydrofolate reductase 1.5.1.3 0.671
4i13 FOLDihydrofolate reductase 1.5.1.3 0.671
4dfr MTXDihydrofolate reductase 1.5.1.3 0.670
4fhb FOLDihydrofolate reductase 1.5.1.3 0.670
4p68 MTXDihydrofolate reductase / 0.670
4x5i FOLDihydrofolate reductase 1.5.1.3 0.670
1u70 MTXDihydrofolate reductase 1.5.1.3 0.668
4i1n FOLDihydrofolate reductase 1.5.1.3 0.668
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.665
1ddr MTXDihydrofolate reductase 1.5.1.3 0.664
1dyi FOLDihydrofolate reductase 1.5.1.3 0.664
1tdr MTXDihydrofolate reductase 1.5.1.3 0.664
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.663
3dau MTXDihydrofolate reductase 1.5.1.3 0.657
4m6k FOLDihydrofolate reductase 1.5.1.3 0.657
1u72 MTXDihydrofolate reductase 1.5.1.3 0.656
1drf FOLDihydrofolate reductase 1.5.1.3 0.655
1dre MTXDihydrofolate reductase 1.5.1.3 0.654
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.652
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.652
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.651