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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dn5 AGS Mitogen-activated protein kinase kinase kinase 14 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.978
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.848
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.846
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.846
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.842
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.826
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.824
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.821
5dn3 ATPAurora kinase A 2.7.11.1 0.819
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.814
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.813
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.810
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.802
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.796
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.789
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.787
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.787
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
4ysj ADPCalmodulin-like domain protein kinase / 0.782
5drd ATPAurora kinase A 2.7.11.1 0.782
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.781
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.777
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.776
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.775
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.773
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.773
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.772
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.769
4dee ADPAurora kinase A 2.7.11.1 0.768
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.766
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.766
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.766
5ce3 ADPProtein kinase YopO / 0.766
1mq4 ADPAurora kinase A 2.7.11.1 0.764
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.763
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.763
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.761
4ceg ADPAurora kinase A 2.7.11.1 0.761
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.761
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.760
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.759
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.758
5dt3 ATPAurora kinase A 2.7.11.1 0.756
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.755
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.755
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.753
4utd ACPAurora kinase A 2.7.11.1 0.751
5dos ATPAurora kinase A 2.7.11.1 0.749
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.748
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.747
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.745
4qny ANPMitogen activated protein kinase, putative / 0.745
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.744
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.744
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.744
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.743
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.741
3c4z ADPRhodopsin kinase / 0.740
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.737
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
4gyi ADPUncharacterized protein / 0.736
3orp AGSSerine/threonine protein kinase / 0.735
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.735
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
2pyw ADPMethylthioribose kinase 2.7.1.100 0.733
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.729
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.729
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.723
5dnr ATPAurora kinase A 2.7.11.1 0.723
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.722
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.721
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.721
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.720
2pup ADPMethylthioribose kinase 2.7.1.100 0.719
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.718
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.718
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.717
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.716
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.716
3nie ANPMitogen-activated protein kinase / 0.716
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.716
3tdw GDPGentamicin resistance protein / 0.715
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.714
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.713
5iqf GDPBifunctional AAC/APH 2.3.1 0.713
3oro AGSSerine/threonine protein kinase / 0.712
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.712
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.711
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.711
3qc9 ADPRhodopsin kinase / 0.710
5dt4 ATPAurora kinase A 2.7.11.1 0.710
3c50 ADPRhodopsin kinase / 0.709
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.706
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.706
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.705
5dr2 ATPAurora kinase A 2.7.11.1 0.704
2olc ADPMethylthioribose kinase 2.7.1.100 0.703
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.703
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.703
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
4bn1 ADPAurora kinase A 2.7.11.1 0.701
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
5eg3 ACPFibroblast growth factor receptor 2 / 0.700
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.699
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.699
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.698
3tdv GDPGentamicin resistance protein / 0.697
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.697
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.695
1m0w ANPGlutathione synthetase 6.3.2.3 0.693
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.693
4xlv ACPInsulin receptor 2.7.10.1 0.693
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.693
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.693
1ol6 ATPAurora kinase A 2.7.11.1 0.692
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
4o0u ADNAurora kinase A 2.7.11.1 0.692
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.691
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.691
4ork GDPBifunctional AAC/APH 2.3.1 0.690
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.689
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.687
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.686
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.686
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.685
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.685
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.683
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.683
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.682
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.681
2py3 ACPFibroblast growth factor receptor 2 / 0.680
3ori AGSSerine/threonine protein kinase / 0.680
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.680
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.680
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.677
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.676
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.676
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.675
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.675
5iqh GNPBifunctional AAC/APH 2.3.1 0.675
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.674
5iqa GNPBifunctional AAC/APH 2.3.1 0.674
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.673
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.673
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
3t8o ATPRhodopsin kinase / 0.672
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.672
4n57 ADPAPH(2'')-Id / 0.672
2pui ADPMethylthioribose kinase 2.7.1.100 0.671
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.671
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.671
1dv2 ATPBiotin carboxylase 6.3.4.14 0.670
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.670
2dwb ANPAurora kinase A 2.7.11.1 0.670
3a8w ATPProtein kinase C iota type 2.7.11.13 0.670
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.670
2pml ANPUncharacterized protein / 0.668
2pul ACPMethylthioribose kinase 2.7.1.100 0.668
3cly ACPFibroblast growth factor receptor 2 / 0.668
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.668
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.668
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4o1p ANPRibonuclease L / 0.668
3bu5 ATPInsulin receptor 2.7.10.1 0.667
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.667
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
5iqi GNPBifunctional AAC/APH 2.3.1 0.667
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.666
2wqe ADPAurora kinase A 2.7.11.1 0.665
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
4o0w ADNAurora kinase A 2.7.11.1 0.664
5ckw ANPUncharacterized protein / 0.664
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.663
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.663
1gy3 ATPCyclin-dependent kinase 2 2.7.11.22 0.662
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.661
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.660
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.660
3c4w ATPRhodopsin kinase / 0.659
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.659
2pun ACPMethylthioribose kinase 2.7.1.100 0.657
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.657
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
4c3r ACPAurora kinase A 2.7.11.1 0.656
3orm AGSSerine/threonine protein kinase / 0.655
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.655
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.655
3llt ANPProtein serine/threonine kinase-1 / 0.654
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.654
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.654
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.654
5iqd GNPBifunctional AAC/APH 2.3.1 0.654
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.653
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.653
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.651
3zo4 QWIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.651
2pzp ACPFibroblast growth factor receptor 2 / 0.650
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.650