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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4djw 0KP Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4djw 0KPBeta-secretase 1 3.4.23.46 0.901
4djv 0KMBeta-secretase 1 3.4.23.46 0.844
4b72 2FBBeta-secretase 1 3.4.23.46 0.790
4dju 0KKBeta-secretase 1 3.4.23.46 0.781
4djy 0KRBeta-secretase 1 3.4.23.46 0.761
4jpc 1M6Beta-secretase 1 3.4.23.46 0.757
4djx 0KQBeta-secretase 1 3.4.23.46 0.752
4b0q GMFBeta-secretase 1 3.4.23.46 0.751
4joo 1M4Beta-secretase 1 3.4.23.46 0.749
4jpe 1M7Beta-secretase 1 3.4.23.46 0.749
4acu QN7Beta-secretase 1 3.4.23.46 0.745
4b05 32DBeta-secretase 1 3.4.23.46 0.710
4jp9 1M5Beta-secretase 1 3.4.23.46 0.692
4b1d 6TGBeta-secretase 1 3.4.23.46 0.669
4b70 WM9Beta-secretase 1 3.4.23.46 0.667
1c5n ESIProthrombin 3.4.21.5 0.665
2q15 3MRBeta-secretase 1 3.4.23.46 0.662
2zfr 46UProthrombin 3.4.21.5 0.657
2zhw 12UProthrombin 3.4.21.5 0.657
3biv 11UProthrombin 3.4.21.5 0.657
2oah QINBeta-secretase 1 3.4.23.46 0.654
4l7j 1W2Beta-secretase 1 3.4.23.46 0.652
4az2 9MUProthrombin 3.4.21.5 0.650