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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dh5 ADP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.103
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.046
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.037
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.030
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.016
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.011
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.011
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.007
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.003
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.997
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.990
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.978
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.971
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.955
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.954
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.946
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.942
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.940
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.939
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.933
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.921
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.919
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.895
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.888
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.886
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.881
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.871
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.863
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.861
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.857
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.854
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.842
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.823
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.808
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.797
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.795
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.790
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.789
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.777
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.774
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.774
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.773
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.772
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.772
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.769
4dee ADPAurora kinase A 2.7.11.1 0.767
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.765
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.764
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.762
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.760
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.758
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.757
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.755
2pui ADPMethylthioribose kinase 2.7.1.100 0.754
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.753
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.752
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.750
5iqh GNPBifunctional AAC/APH 2.3.1 0.748
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.746
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.744
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.744
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.744
4ysj ADPCalmodulin-like domain protein kinase / 0.744
4qny ANPMitogen activated protein kinase, putative / 0.743
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.741
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.740
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.739
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.739
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.739
5dr2 ATPAurora kinase A 2.7.11.1 0.737
1mq4 ADPAurora kinase A 2.7.11.1 0.736
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.736
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.735
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.733
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.732
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.730
4bn1 ADPAurora kinase A 2.7.11.1 0.730
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.729
2pup ADPMethylthioribose kinase 2.7.1.100 0.728
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.726
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.725
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.725
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.723
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.722
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.722
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.720
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.717
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.717
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.717
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.715
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.715
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.714
4xlv ACPInsulin receptor 2.7.10.1 0.714
5dt3 ATPAurora kinase A 2.7.11.1 0.714
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.713
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.711
2olc ADPMethylthioribose kinase 2.7.1.100 0.711
2pz5 ACPFibroblast growth factor receptor 2 / 0.711
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.710
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.710
5dn3 ATPAurora kinase A 2.7.11.1 0.710
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.709
5iqb GNPBifunctional AAC/APH 2.3.1 0.709
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.708
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.705
5iqe GNPBifunctional AAC/APH 2.3.1 0.705
1jdb ADPCarbamoyl-phosphate synthase large chain / 0.704
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.704
4ffl ADPUncharacterized protein / 0.704
5ce3 ADPProtein kinase YopO / 0.704
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.703
4ork GDPBifunctional AAC/APH 2.3.1 0.703
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.701
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.700
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.699
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.699
3q5i ANPProtein kinase, putative / 0.698
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.698
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.697
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.697
4utd ACPAurora kinase A 2.7.11.1 0.697
5dos ATPAurora kinase A 2.7.11.1 0.696
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.695
4o1p ANPRibonuclease L / 0.694
5iqa GNPBifunctional AAC/APH 2.3.1 0.694
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.693
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.692
2dwb ANPAurora kinase A 2.7.11.1 0.692
2uvy GVIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.692
2vqd AP2Biotin carboxylase 6.3.4.14 0.691
3c4z ADPRhodopsin kinase / 0.691
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.691
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.690
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.690
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.689
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.689
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.689
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.689
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.689
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.687
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.686
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.686
2pml ANPUncharacterized protein / 0.685
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.685
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.684
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.684
3cly ACPFibroblast growth factor receptor 2 / 0.683
3g8d ADPBiotin carboxylase 6.3.4.14 0.683
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.683
4o0w ADNAurora kinase A 2.7.11.1 0.682
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.681
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.681
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.681
4gyi ADPUncharacterized protein / 0.680
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.679
3a8w ATPProtein kinase C iota type 2.7.11.13 0.679
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.679
2py3 ACPFibroblast growth factor receptor 2 / 0.678
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.677
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.677
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.676
2qen ADPWalker-Type ATPase / 0.676
4ceg ADPAurora kinase A 2.7.11.1 0.676
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.675
2vo0 M03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
3c50 ADPRhodopsin kinase / 0.674
3t8o ATPRhodopsin kinase / 0.674
4yxs EMUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
5iqf GDPBifunctional AAC/APH 2.3.1 0.674
3mvj XFEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5dnr ATPAurora kinase A 2.7.11.1 0.673
2pul ACPMethylthioribose kinase 2.7.1.100 0.672
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.672
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.672
1m0w ANPGlutathione synthetase 6.3.2.3 0.671
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.671
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.671
5drd ATPAurora kinase A 2.7.11.1 0.671
1i44 ACPInsulin receptor 2.7.10.1 0.670
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.670
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.670
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.670
5eg3 ACPFibroblast growth factor receptor 2 / 0.669
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.668
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.667
3bu5 ATPInsulin receptor 2.7.10.1 0.667
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.667
2pzp ACPFibroblast growth factor receptor 2 / 0.666
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.666
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.666
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.666
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.665
2o8b ADPDNA mismatch repair protein Msh2 / 0.665
1cm8 ANPMitogen-activated protein kinase 12 / 0.664
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.664
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.664
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.663
3iew CDP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 0.663
3tdv GDPGentamicin resistance protein / 0.663
3rv4 ADPBiotin carboxylase 6.3.4.14 0.662
4ffr ATPUncharacterized protein / 0.662
1ir3 ANPInsulin receptor 2.7.10.1 0.661
4xeo A5AAlanine--tRNA ligase, cytoplasmic / 0.661
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.660
3wo0 ADPAlanine--anticapsin ligase / 0.660
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.660
3orm AGSSerine/threonine protein kinase / 0.659
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.659
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.658
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.658
5iqi GNPBifunctional AAC/APH 2.3.1 0.658
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.656
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.655
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.655
3llt ANPProtein serine/threonine kinase-1 / 0.655
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.655
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.654
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.654
4q5h ANPProtein kinase OspG 2.7 0.654
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.653
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.653
4o0s ADNAurora kinase A 2.7.11.1 0.653
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.652
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.652
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.652
5byl GCPBifunctional AAC/APH 2.3.1 0.652
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.652
2zdg ADPD-alanine--D-alanine ligase / 0.651
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
3nie ANPMitogen-activated protein kinase / 0.651
3tdw GDPGentamicin resistance protein / 0.651
3zo4 QWIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
4j95 ACPFibroblast growth factor receptor 2 / 0.651
4s26 SAHPhosphomethylpyrimidine synthase, chloroplastic 4.1.99.17 0.651
5g53 NECAdenosine receptor A2a / 0.651
3umo ATPATP-dependent 6-phosphofructokinase isozyme 2 2.7.1.11 0.650