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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dh0 MR8 Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dh0 MR8Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 1.103
1fkj FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.877
2fke FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.876
4dz2 FK5Peptidyl-prolyl cis-trans isomerase / 0.871
1qpl 587Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.848
4lay I63Peptidyl-prolyl cis-trans isomerase FKBP4 5.2.1.8 0.838
1fkf FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.836
1bkf FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.829
4fap ARDPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.823
4fap ARDSerine/threonine-protein kinase mTOR 2.7.11.1 0.823
4dri RAPSerine/threonine-protein kinase mTOR 2.7.11.1 0.820
4dri RAPPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.820
1fkd 818Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.818
4drm 0MCPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.815
2dg3 RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.796
4drn 0MCPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.787
1fkb RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.786
3ihz FK5Peptidylprolyl isomerase / 0.780
2dg9 RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.777
4odo FK5Peptidyl-prolyl cis-trans isomerase / 0.776
1qpf 858Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.763
4drk I63Peptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.753
1fkl RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.752
4drp 0MDPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.752
1c9h RAPPeptidyl-prolyl cis-trans isomerase FKBP1B 5.2.1.8 0.747
4qt3 RAPPeptidylprolyl isomerase / 0.747
2vn1 FK5Peptidylprolyl isomerase / 0.745
1tco FK5Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.743
1tco FK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 3.1.3.16 0.743
1nsg RADPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.742
1nsg RADSerine/threonine-protein kinase mTOR 2.7.11.1 0.742
2fap RADPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.742
2fap RADSerine/threonine-protein kinase mTOR 2.7.11.1 0.742
4dro 0MDPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.742
1bl4 AP1Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.733
1fki SB1Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.730
4drj RAPSerine/threonine-protein kinase mTOR 2.7.11.1 0.730
4drj RAPPeptidyl-prolyl cis-trans isomerase FKBP4 5.2.1.8 0.730
1fkh SBXPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.716
1j4h SUBPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.714
1fkg SB3Peptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.713
3o5r FK5Peptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.705
2dg4 RAPPeptidyl-prolyl cis-trans isomerase FKBP1A 5.2.1.8 0.680
4drh RAPSerine/threonine-protein kinase mTOR 2.7.11.1 0.677
4drh RAPPeptidyl-prolyl cis-trans isomerase FKBP5 5.2.1.8 0.677