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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4df2 FMN NADPH dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4df2 FMNNADPH dehydrogenase / 1.269
3tjl FMNNADPH dehydrogenase / 1.232
4m5p FMNNADPH dehydrogenase / 1.225
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 1.141
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 1.127
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 1.125
4tmc FMNOld yellow enzyme / 1.096
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 1.089
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 1.079
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 1.058
1oya FMNNADPH dehydrogenase 1 1.6.99.1 1.052
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 1.046
3f03 FMNPentaerythritol tetranitrate reductase / 1.044
3p84 FMNPentaerythritol tetranitrate reductase / 1.036
3p8j FMNPentaerythritol tetranitrate reductase / 1.018
1gwj FMNMorphinone reductase / 1.017
4utm FNRXenobiotic reductase / 1.012
3l67 FMNXenobiotic reductase / 1.011
4utk FNRXenobiotic reductase / 1.009
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.995
3n14 FMNXenobiotic reductase / 0.981
3l5l FMNXenobiotic reductase / 0.972
4uth FMNXenobiotic reductase / 0.972
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.969
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.966
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.965
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.959
4tmb FMNOld yellow enzyme / 0.959
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.956
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.953
4utl FNRXenobiotic reductase / 0.945
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.940
3gka FMNN-ethylmaleimide reductase / 0.933
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.925
3atz FMNProstaglandin F2a synthase / 0.924
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.924
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.921
3p74 FMNPentaerythritol tetranitrate reductase / 0.917
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.909
2h8x FMNXenA / 0.906
4qai FMNNADPH dehydrogenase / 0.899
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.898
3aty FMNProstaglandin F2a synthase / 0.898
4e2b FMNDehydrogenase / 0.895
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.894
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.884
1h63 FMNPentaerythritol tetranitrate reductase / 0.884
3p67 FMNPentaerythritol tetranitrate reductase / 0.884
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.881
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.879
3hf3 FMNChromate reductase / 0.878
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.878
4e2d FMNDehydrogenase / 0.874
3p8i FMNPentaerythritol tetranitrate reductase / 0.870
1h50 FMNPentaerythritol tetranitrate reductase / 0.867
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.858
1h51 FMNPentaerythritol tetranitrate reductase / 0.852
3gr8 FMNNADPH dehydrogenase / 0.852
2abb FMNPentaerythritol tetranitrate reductase / 0.851
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.841
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.836
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.835
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.830
1z48 FMNNADPH dehydrogenase / 0.829
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.829
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.827
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.826
4yco FMNtRNA-dihydrouridine(16) synthase / 0.825
1vyr FMNPentaerythritol tetranitrate reductase / 0.806
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.791
1z41 FMNNADPH dehydrogenase / 0.785
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.783
1z44 FMNNADPH dehydrogenase / 0.782
3p82 FMNPentaerythritol tetranitrate reductase / 0.775
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.771
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.764
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.749
3oix FMNDihydroorotate dehydrogenase / 0.748
5ebu FMNLactate oxidase / 0.743
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.738
3n19 FNRXenobiotic reductase / 0.738
2z6i FMN2-nitropropane dioxygenase / 0.731
4yl2 FMNLactate oxidase / 0.726
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.724
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.723
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.720
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.718
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.718
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.716
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.715
4cw5 FMNDfnA / 0.710
2fzm FADBifunctional protein PutA 1.5.5.2 0.708
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.708
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.705
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.703
2j6x FMNLactate oxidase / 0.702
4l82 FMNUncharacterized protein / 0.695
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.692
2gjn FMNNitronate monooxygenase 1.13.12.16 0.692
3p62 FMNPentaerythritol tetranitrate reductase / 0.691
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.689
2e77 FMNLactate oxidase / 0.689
4jic FMNGTN Reductase / 0.689
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.689
4j8p FMNFlavodoxin / 0.686
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.680
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.678
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.678
2du2 FMNLactate oxidase / 0.677
2z9d FMNFMN-dependent NADH-azoreductase / 0.674
4h6r FDAProline dehydrogenase / 0.671
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.666
2gjl FMNNitronate monooxygenase 1.13.12.16 0.665
4hmx FMNPyridoxamine 5'-phosphate oxidase / 0.664
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.663
4bmo FMNProtein NrdI / 0.661
5eai FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.661
4hj3 FMNLOV protein / 0.660
4nmc FADBifunctional protein PutA / 0.660
2zfa FMNLactate oxidase / 0.659
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.659
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.657
2bf4 FMNNADPH--cytochrome P450 reductase / 0.656
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.656
3rup ADPBiotin carboxylase 6.3.4.14 0.656
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.655
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.654
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.654
4n82 FMNRibonucleotide reductase (NrdI family protein), putative / 0.654
3lcm FADPutative oxidoreductase / 0.653
4nm9 FADBifunctional protein PutA / 0.653
1s4m LUMRiboflavin biosynthesis protein / 0.652
4hnb FMNLOV protein / 0.652
4ejm NAPPutative zinc-binding dehydrogenase / 0.651