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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4d58 BI9 Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4d58 BI9Focal adhesion kinase 1 2.7.10.2 1.057
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.946
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.763
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.759
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.739
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.725
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.706
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.705
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.699
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.698
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.696
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.694
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.690
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.689
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.684
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.680
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.675
1oec AA2Fibroblast growth factor receptor 2 / 0.670
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.666
2euf LQQCyclin-dependent kinase 6 2.7.11.22 0.665
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.665
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.664
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.663
3v5l 0G1Tyrosine-protein kinase ITK/TSK 2.7.10.2 0.661
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.659
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.655
3rzb 02ZCyclin-dependent kinase 2 2.7.11.22 0.655
3lpb NVBTyrosine-protein kinase JAK2 / 0.653
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.652
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.651
4fv4 EK7Mitogen-activated protein kinase 1 2.7.11.24 0.651