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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4d03 FAD Phenylacetone monooxygenase 1.14.13.92

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4d03 FADPhenylacetone monooxygenase 1.14.13.92 1.487
4d04 FADPhenylacetone monooxygenase 1.14.13.92 1.459
2ylx FADPhenylacetone monooxygenase 1.14.13.92 1.414
2ylr FADPhenylacetone monooxygenase 1.14.13.92 1.384
2yls FADPhenylacetone monooxygenase 1.14.13.92 1.374
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 1.306
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 1.287
2ylt FADPhenylacetone monooxygenase 1.14.13.92 1.283
2ylw FADPhenylacetone monooxygenase 1.14.13.92 1.213
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.027
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.022
3gwd FADCyclohexanone monooxygenase / 1.006
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.971
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.967
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.945
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.890
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.869
3gwf FADCyclohexanone monooxygenase / 0.833
2vqb FADPutative flavin-containing monooxygenase / 0.807
4b64 FADL-ornithine N(5)-monooxygenase / 0.801
4tlz FADKtzI / 0.790
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.788
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.786
1y56 ATPUncharacterized protein / 0.783
4b69 FADL-ornithine N(5)-monooxygenase / 0.783
3ish FADThioredoxin reductase 1.8.1.9 0.781
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.775
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.773
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.772
1f3p FADFerredoxin reductase / 0.771
3qvp FADGlucose oxidase 1.1.3.4 0.766
4ap3 FADSteroid monooxygenase / 0.766
4b63 FADL-ornithine N(5)-monooxygenase / 0.763
4em3 FADCoenzyme A disulfide reductase / 0.758
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.755
2gv8 FADThiol-specific monooxygenase 1.14.13 0.755
3qvr FADGlucose oxidase 1.1.3.4 0.754
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.752
1zx9 FADMercuric reductase 1.16.1.1 0.749
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.749
2xls FADPutative flavin-containing monooxygenase / 0.748
1get FADGlutathione reductase 1.8.1.7 0.745
2xlp FADPutative flavin-containing monooxygenase / 0.744
4ap1 FADSteroid monooxygenase / 0.744
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.740
2q7v FADThioredoxin reductase / 0.740
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.739
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.738
3utf FDAUDP-galactopyranose mutase / 0.737
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.736
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.735
1k0l FADp-hydroxybenzoate hydroxylase / 0.734
3rha FDAPutrescine oxidase / 0.733
4yry FADGlutamate synthase, beta subunit / 0.733
4z26 FADPutative GMC-type oxidoreductase R135 1 0.733
4eqw FADCoenzyme A disulfide reductase / 0.732
4z24 FADPutative GMC-type oxidoreductase R135 1 0.732
1ger FADGlutathione reductase 1.8.1.7 0.731
4tm3 FADKtzI / 0.730
2gvc FADThiol-specific monooxygenase 1.14.13 0.729
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.729
4b65 FADL-ornithine N(5)-monooxygenase / 0.729
5cku FADL-ornithine N(5)-monooxygenase / 0.728
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.727
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.727
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.726
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.723
3nlc FADUncharacterized protein / 0.723
4u8p FDAUDP-galactopyranose mutase / 0.723
3hdy FADUDP-galactopyranose mutase / 0.722
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.718
2xvf FADPutative flavin-containing monooxygenase / 0.717
1qo8 FADFumarate reductase flavoprotein subunit / 0.714
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.713
3f8p NADNADH oxidase/thioredoxin reductase / 0.713
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.712
4u2t FADCholesterol oxidase 1.1.3.6 0.711
3s5w FADL-ornithine N(5)-monooxygenase / 0.710
4em4 FADCoenzyme A disulfide reductase / 0.710
1f8r FADL-amino-acid oxidase 1.4.3.2 0.709
1gal FADGlucose oxidase 1.1.3.4 0.707
3ad9 NADSubunit alpha of sarocosine oxidase / 0.707
4aox FADSteroid monooxygenase / 0.706
4emw FADCoenzyme A disulfide reductase / 0.705
4b66 FADL-ornithine N(5)-monooxygenase / 0.704
4b67 FADL-ornithine N(5)-monooxygenase / 0.703
3ics FADCoenzyme A disulfide reductase / 0.702
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.700
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.700
3f8r NAPNADH oxidase/thioredoxin reductase / 0.696
3kve FADL-amino-acid oxidase / 0.696
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.694
4rek FADCholesterol oxidase 1.1.3.6 0.694
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.693
2xlr FADPutative flavin-containing monooxygenase / 0.693
4aos FADSteroid monooxygenase / 0.693
4eqs FADCoenzyme A disulfide reductase / 0.693
2rgh FADAlpha-Glycerophosphate Oxidase / 0.692
2xvi FADPutative flavin-containing monooxygenase / 0.692
1cbo FADCholesterol oxidase 1.1.3.6 0.690
1ges FADGlutathione reductase 1.8.1.7 0.690
2whd FADThioredoxin reductase / 0.690
3r9u FADThioredoxin reductase / 0.690
3ada NADSubunit alpha of sarocosine oxidase / 0.689
4qi7 FADCellobiose dehydrogenase / 0.689
1ryi FADGlycine oxidase 1.4.3.19 0.688
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.688
2yvf FADFerredoxin reductase / 0.688
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.688
3ihg FADAklavinone 12-hydroxylase RdmE / 0.686
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.686
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.685
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.685
4u8m FDAUDP-galactopyranose mutase / 0.685
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.684
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.684
1cf3 FADGlucose oxidase 1.1.3.4 0.683
2igo FADPyranose 2-oxidase / 0.683
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.683
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.681
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.680
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.679
2xvh FADPutative flavin-containing monooxygenase / 0.679
3b6d FAECholesterol oxidase 1.1.3.6 0.678
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.677
4mih FADPyranose 2-oxidase 1.1.3.10 0.676
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.675
2vvl FADMonoamine oxidase N 1.4.3.4 0.675
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.675
3syi FADSulfide-quinone reductase / 0.675
3t37 FADPyridoxine 4-oxidase / 0.675
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.675
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.674
2gr3 FADFerredoxin reductase / 0.674
2r0c FADPutative FAD-monooxygenase / 0.674
3cox FADCholesterol oxidase 1.1.3.6 0.674
2eq6 FADDihydrolipoyl dehydrogenase / 0.673
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.671
1nhq FADNADH peroxidase 1.11.1.1 0.669
4jnq FDAThioredoxin reductase / 0.669
1h83 FADPolyamine oxidase 1.5.3.14 0.668
2hqm FADGlutathione reductase 1.8.1.7 0.668
2jae FADL-amino acid oxidase / 0.668
2wba FADTrypanothione reductase 1.8.1.12 0.668
4eqx FADCoenzyme A disulfide reductase / 0.668
4fwe FADLysine-specific histone demethylase 1B 1 0.668
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.667
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.667
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.667
3g8a SAHRibosomal RNA small subunit methyltransferase G / 0.666
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.666
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.666
3zdn FADMonoamine oxidase N 1.4.3.4 0.666
2jb2 FADL-amino acid oxidase / 0.665
3f8d FADNADH oxidase/thioredoxin reductase / 0.665
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.665
3jsk AHZThiamine thiazole synthase / 0.665
1ib0 FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.664
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.664
4mo2 FADUDP-galactopyranose mutase / 0.664
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.663
4mok FADPyranose 2-oxidase / 0.663
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.663
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.662
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.662
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.662
1fea FADTrypanothione reductase 1.8.1.12 0.661
3k30 ADPHistamine dehydrogenase / 0.661
3mj4 FADUDP-galactopyranose mutase / 0.661
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.660
3icr FADCoenzyme A disulfide reductase / 0.660
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.660
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.659
1nhr FADNADH peroxidase 1.11.1.1 0.659
3bi2 FADPolyamine oxidase FMS1 / 0.659
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.659
4jq9 FADDihydrolipoyl dehydrogenase / 0.659
1bzl FADTrypanothione reductase 1.8.1.12 0.658
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.658
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
1h81 FADPolyamine oxidase 1.5.3.14 0.657
1yy5 FADPolyamine oxidase FMS1 / 0.657
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.657
2rgj FADFlavin-containing monooxygenase / 0.657
2eq7 FADDihydrolipoyl dehydrogenase / 0.656
2hmv ADPKtr system potassium uptake protein A / 0.656
2gr1 FADFerredoxin reductase / 0.655
3fg2 FADPutative rubredoxin reductase / 0.655
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.655
1nhs FADNADH peroxidase 1.11.1.1 0.654
1v59 NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.654
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.654
1geu FADGlutathione reductase 1.8.1.7 0.653
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.653
1ndh FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.653
3bg7 FADPyranose 2-oxidase / 0.653
3ka7 FADPutative oxidoreductase / 0.653
4yjd FADD-amino-acid oxidase 1.4.3.3 0.653
2xve FADPutative flavin-containing monooxygenase / 0.652
3cgc FADCoenzyme A disulfide reductase / 0.652
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.652
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.652
1n4w FADCholesterol oxidase 1.1.3.6 0.651
3pl8 FADPyranose 2-oxidase / 0.651
4wct FADFructosyl amine:oxygen oxidoreductase / 0.651
4xwr FADCholesterol oxidase 1.1.3.6 0.651
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.651
3cty FADProbable thioredoxin reductase / 0.650
3gyj FADCholesterol oxidase 1.1.3.6 0.650
3ukf FDAUDP-galactopyranose mutase / 0.650
4xxg FADCholesterol oxidase 1.1.3.6 0.650
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.650