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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4cw5 FMN DfnA

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4cw5 FMNDfnA / 1.039
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.840
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.822
1vhn FMNtRNA-dihydrouridine synthase / 0.782
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.775
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.769
2gjl FMNNitronate monooxygenase 1.13.12.16 0.768
3l67 FMNXenobiotic reductase / 0.763
1z48 FMNNADPH dehydrogenase / 0.759
2gjn FMNNitronate monooxygenase 1.13.12.16 0.757
1z41 FMNNADPH dehydrogenase / 0.752
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.750
3hf3 FMNChromate reductase / 0.750
4z38 FMNMlnA / 0.750
2h8x FMNXenA / 0.749
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.748
3l5l FMNXenobiotic reductase / 0.747
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.743
4utk FNRXenobiotic reductase / 0.742
4utm FNRXenobiotic reductase / 0.742
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.739
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.739
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.734
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.732
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.732
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.731
4uth FMNXenobiotic reductase / 0.730
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.724
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.724
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.723
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.723
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.719
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.719
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.718
3n14 FMNXenobiotic reductase / 0.718
1z44 FMNNADPH dehydrogenase / 0.715
4yco FMNtRNA-dihydrouridine(16) synthase / 0.715
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.713
3n19 FNRXenobiotic reductase / 0.713
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.711
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.710
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.710
3p8i FMNPentaerythritol tetranitrate reductase / 0.710
4df2 FMNNADPH dehydrogenase / 0.710
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.709
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.707
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.706
3tjl FMNNADPH dehydrogenase / 0.705
5cpm FNRNADH:flavin oxidoreductase / 0.705
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.704
2zfa FMNLactate oxidase / 0.704
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.704
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.704
1gwj FMNMorphinone reductase / 0.701
3klb FMNUncharacterized protein / 0.701
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.699
4e2d FMNDehydrogenase / 0.698
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.697
4gi5 FADPutative NAD(P)H dehydrogenase (Quinone) / 0.697
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.696
3p8j FMNPentaerythritol tetranitrate reductase / 0.695
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.694
3p84 FMNPentaerythritol tetranitrate reductase / 0.694
4tmc FMNOld yellow enzyme / 0.694
1h63 FMNPentaerythritol tetranitrate reductase / 0.693
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.693
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.692
2abb FMNPentaerythritol tetranitrate reductase / 0.692
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.692
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.692
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.691
3aty FMNProstaglandin F2a synthase / 0.691
4qai FMNNADPH dehydrogenase / 0.691
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.690
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.690
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.690
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.690
2nli FMNLactate oxidase / 0.690
2z6i FMN2-nitropropane dioxygenase / 0.690
4tmb FMNOld yellow enzyme / 0.689
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.687
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.687
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.686
3atz FMNProstaglandin F2a synthase / 0.685
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.685
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.684
4e2b FMNDehydrogenase / 0.684
2ohj FMNType A flavoprotein FprA 1 0.683
4jic FMNGTN Reductase / 0.682
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.681
1vyr FMNPentaerythritol tetranitrate reductase / 0.680
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.679
3p74 FMNPentaerythritol tetranitrate reductase / 0.678
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.677
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.677
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.675
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.675
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.675
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.675
4ttc FMNIodotyrosine deiodinase 1 / 0.675
4hnb FMNLOV protein / 0.674
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.673
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.673
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.672
5jsc FADPutative acyl-CoA dehydrogenase / 0.672
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.671
1h50 FMNPentaerythritol tetranitrate reductase / 0.669
2pg0 FADAcyl-CoA dehydrogenase / 0.669
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.668
2j6x FMNLactate oxidase / 0.668
2pr5 FMNBlue-light photoreceptor / 0.665
3oix FMNDihydroorotate dehydrogenase / 0.663
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.663
4j8p FMNFlavodoxin / 0.661
1akw FMNFlavodoxin / 0.659
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.659
5i39 FADL-amino acid deaminase / 0.658
3gr8 FMNNADPH dehydrogenase / 0.657
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.654
2ohh FMNType A flavoprotein FprA 1 0.654
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.654
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.653
2eba FADPutative glutaryl-CoA dehydrogenase / 0.653
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.652
1zwl FMNNAD(P)H dehydrogenase (quinone) 1.6.5.2 0.651
3eo8 FMNPutative nitroreductase / 0.651
3p82 FMNPentaerythritol tetranitrate reductase / 0.651
4b63 FADL-ornithine N(5)-monooxygenase / 0.651
3bw3 FMNPutative 2-nitropropane dioxygenase / 0.650