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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4cth RDF Neprilysin

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4cth RDFNeprilysin / 1.244
4zr5 RDFNeprilysin / 0.997
3zuk RDFEndopeptidase, peptidase family M13 / 0.907
4d9w X32Thermolysin 3.4.24.27 0.867
4h57 0PJThermolysin 3.4.24.27 0.822
3t8d UBVThermolysin 3.4.24.27 0.814
3dwb RDFEndothelin-converting enzyme 1 3.4.24.71 0.808
3t8c UBWThermolysin 3.4.24.27 0.798
4tmn 0PKThermolysin 3.4.24.27 0.798
4b52 RDFBacillolysin / 0.792
3fv4 1U4Thermolysin 3.4.24.27 0.782
3t74 UBYThermolysin 3.4.24.27 0.782
3fvp UB2Thermolysin 3.4.24.27 0.775
1u4g HPIElastase 3.4.24.26 0.767
6tmn 0PIThermolysin 3.4.24.27 0.742
1r1j OIRNeprilysin / 0.741
1r1i TI1Neprilysin / 0.672
3t87 UBZThermolysin 3.4.24.27 0.660