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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ct2 ATP 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.885
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.730
3ork AGSSerine/threonine protein kinase / 0.718
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.717
3orp AGSSerine/threonine protein kinase / 0.709
3ort AGSSerine/threonine protein kinase / 0.708
2wqe ADPAurora kinase A 2.7.11.1 0.707
4ct1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.707
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.698
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.696
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.696
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.696
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.692
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.689
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.688
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.686
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.686
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.683
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
1h1w ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.681
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.681
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.679
2biy ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.678
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.678
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.677
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.677
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.675
4rqv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.675
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.672
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.672
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.672
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.671
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.670
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.669
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.669
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.667
4jrn ANPRhoptry kinase family protein / 0.667
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.665
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.665
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.665
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
4ysj ADPCalmodulin-like domain protein kinase / 0.665
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.664
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.664
5dr2 ATPAurora kinase A 2.7.11.1 0.663
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.662
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.661
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4c3r ACPAurora kinase A 2.7.11.1 0.660
3nie ANPMitogen-activated protein kinase / 0.659
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.659
1ir3 ANPInsulin receptor 2.7.10.1 0.658
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.658
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.658
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.657
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.657
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.656
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.656
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.656
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.656
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.655
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.652
3c4z ADPRhodopsin kinase / 0.652
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.651
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.650
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650