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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4crs AGS Serine/threonine-protein kinase N2 2.7.11.13

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.967
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.716
5ce3 ADPProtein kinase YopO / 0.711
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.708
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.704
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.701
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.700
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.700
4ysj ADPCalmodulin-like domain protein kinase / 0.700
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.699
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
4dee ADPAurora kinase A 2.7.11.1 0.692
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.690
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.689
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.689
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.687
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.687
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.687
3tw6 ADPPyruvate carboxylase / 0.687
3rv4 ADPBiotin carboxylase 6.3.4.14 0.683
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.682
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4bix ADPSensor histidine kinase CpxA / 0.681
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.681
2pml ANPUncharacterized protein / 0.680
4xlv ACPInsulin receptor 2.7.10.1 0.679
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.677
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.676
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.675
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.674
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.673
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.673
5dr2 ATPAurora kinase A 2.7.11.1 0.673
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.672
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.671
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.670
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.669
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.669
5dt3 ATPAurora kinase A 2.7.11.1 0.669
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.667
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.667
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.665
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.663
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.663
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.661
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.661
4a06 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.661
4ceg ADPAurora kinase A 2.7.11.1 0.661
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.661
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.661
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.659
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.659
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.658
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
5dn3 ATPAurora kinase A 2.7.11.1 0.658
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.657
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.657
4gyi ADPUncharacterized protein / 0.656
4rqv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.655
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.655
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.655
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.654
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.654
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
1mq4 ADPAurora kinase A 2.7.11.1 0.653
5drd ATPAurora kinase A 2.7.11.1 0.653
3oii SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.652
4ct1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.652
4lrj ANPUncharacterized protein / 0.652
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.652
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
4bn1 ADPAurora kinase A 2.7.11.1 0.651
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
4xcj ADPHeat shock cognate 90 kDa protein / 0.651
3c4z ADPRhodopsin kinase / 0.650
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.650
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.650
4xcl AGSHeat shock cognate 90 kDa protein / 0.650
4zme ADNMyosin heavy chain kinase A 2.7.11.7 0.650