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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4cki ADN Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.788
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.770
3b2t M33Fibroblast growth factor receptor 2 / 0.747
4e5i 0N9Polymerase acidic protein / 0.744
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.716
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.709
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.709
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.708
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.702
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.702
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.702
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.700
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.700
3cly ACPFibroblast growth factor receptor 2 / 0.699
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.699
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.696
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.695
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.693
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.691
2pwl ACPFibroblast growth factor receptor 2 / 0.689
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.689
4xhg ADPUncharacterized protein / 0.687
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.685
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.685
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.684
4j99 ACPFibroblast growth factor receptor 2 / 0.684
1ir3 ANPInsulin receptor 2.7.10.1 0.683
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.683
4c3p ACPAurora kinase A 2.7.11.1 0.683
4c3r ACPAurora kinase A 2.7.11.1 0.683
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.682
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.682
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.681
3pls ANPMacrophage-stimulating protein receptor 2.7.10.1 0.681
4j97 ACPFibroblast growth factor receptor 2 / 0.681
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.680
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.680
4b8l A0PAurora kinase B-A 2.7.11.1 0.680
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.680
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.679
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.679
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.679
2pz5 ACPFibroblast growth factor receptor 2 / 0.678
3juh ANPCasein kinase II subunit alpha 2.7.11.1 0.678
4utd ACPAurora kinase A 2.7.11.1 0.678
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.677
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.677
2pvy ACPFibroblast growth factor receptor 2 / 0.676
2py3 ACPFibroblast growth factor receptor 2 / 0.676
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.676
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.675
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.675
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.675
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.675
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.675
1ol6 ATPAurora kinase A 2.7.11.1 0.674
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.674
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.674
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.674
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.673
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.673
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.673
4ix6 ADPUncharacterized protein / 0.673
4j95 ACPFibroblast growth factor receptor 2 / 0.673
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.673
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.672
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.672
2wqe ADPAurora kinase A 2.7.11.1 0.672
3c4w ATPRhodopsin kinase / 0.672
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.672
3t8o ATPRhodopsin kinase / 0.672
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4ysj ADPCalmodulin-like domain protein kinase / 0.672
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.671
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.671
4ix4 ADPUncharacterized protein / 0.671
1b39 ATPCyclin-dependent kinase 2 2.7.11.22 0.670
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.670
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.670
5dnr ATPAurora kinase A 2.7.11.1 0.670
5dt4 ATPAurora kinase A 2.7.11.1 0.670
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.669
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.669
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.668
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.668
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.667
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
3d5w ADPSerine/threonine-protein kinase PLK / 0.667
5dn3 ATPAurora kinase A 2.7.11.1 0.667
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.666
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.666
5dt3 ATPAurora kinase A 2.7.11.1 0.666
5l8l ADPAurora kinase A 2.7.11.1 0.666
2dwb ANPAurora kinase A 2.7.11.1 0.665
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.665
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.665
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.665
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.664
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.663
2g2f AGSTyrosine-protein kinase ABL1 2.7.10.2 0.663
4dee ADPAurora kinase A 2.7.11.1 0.663
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.662
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.662
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4ax8 ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.662
4ceg ADPAurora kinase A 2.7.11.1 0.662
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.661
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.661
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.660
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4ct1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gt8 ADPSensor protein VraS 2.7.13.3 0.660
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.659
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.659
4c2w ANPAurora kinase B-A 2.7.11.1 0.659
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.659
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.659
1ad5 ANPTyrosine-protein kinase HCK 2.7.10.2 0.658
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.658
3nie ANPMitogen-activated protein kinase / 0.658
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4f1o ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.658
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.658
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.658
1i59 ADPChemotaxis protein CheA 2.7.13.3 0.657
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.657
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.657
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.657
1h1w ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
2pzp ACPFibroblast growth factor receptor 2 / 0.656
2yee 2ECHeat shock protein HSP 90-alpha / 0.656
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.656
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.655
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.655
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.655
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.655
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.655
4mv4 ACPBiotin carboxylase 6.3.4.14 0.655
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.654
2pyw ADPMethylthioribose kinase 2.7.1.100 0.654
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.654
3ori AGSSerine/threonine protein kinase / 0.654
4dt8 ADNAPH(2'')-Id / 0.654
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.654
4xlv ACPInsulin receptor 2.7.10.1 0.654
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.654
1i58 ADPChemotaxis protein CheA 2.7.13.3 0.653
2i8c ADPD-alanine--D-alanine ligase / 0.653
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.653
3c50 ADPRhodopsin kinase / 0.653
3hx4 ANPCalmodulin-domain protein kinase 1 / 0.653
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.653
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.651
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.651
2ddo ATPPyridoxine/pyridoxal/pyridoxamine kinase / 0.651
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.651
3mvj XFEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.650