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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ccr FAD Thioredoxin reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ccr FADThioredoxin reductase / 1.271
4cbq FADThioredoxin reductase / 1.105
4ccq FADThioredoxin reductase / 1.101
4a5l FADThioredoxin reductase / 1.089
4up3 FADThioredoxin reductase / 1.089
2whd FADThioredoxin reductase / 1.012
4a65 FADThioredoxin reductase / 1.001
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.962
3ish FADThioredoxin reductase 1.8.1.9 0.958
3d8x FADThioredoxin reductase 1 1.8.1.9 0.932
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.896
2q0k FADThioredoxin reductase 1.8.1.9 0.889
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.888
4gcm FADThioredoxin reductase 1.8.1.9 0.887
3r9u FADThioredoxin reductase / 0.856
1tde FADThioredoxin reductase 1.8.1.9 0.849
3itj FADThioredoxin reductase 1 1.8.1.9 0.841
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.840
1tdf FADThioredoxin reductase 1.8.1.9 0.837
3f8d FADNADH oxidase/thioredoxin reductase / 0.836
1trb FADThioredoxin reductase 1.8.1.9 0.824
4jnq FDAThioredoxin reductase / 0.824
2q7v FADThioredoxin reductase / 0.822
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.819
4fwe FADLysine-specific histone demethylase 1B 1 0.815
4hsu FADLysine-specific histone demethylase 1B 1 0.815
2q0l FADThioredoxin reductase 1.8.1.9 0.813
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.808
1bzl FADTrypanothione reductase 1.8.1.12 0.796
3nlc FADUncharacterized protein / 0.796
1feb FADTrypanothione reductase 1.8.1.12 0.785
4nev FADTrypanothione reductase / 0.785
1get FADGlutathione reductase 1.8.1.7 0.783
1typ FADTrypanothione reductase 1.8.1.12 0.781
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.780
2r9z FADGlutathione amide reductase / 0.778
4gut FADLysine-specific histone demethylase 1B 1 0.778
3fbs FADOxidoreductase / 0.774
1ger FADGlutathione reductase 1.8.1.7 0.773
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.766
4nte FADDepH / 0.762
2wba FADTrypanothione reductase 1.8.1.12 0.761
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.761
3ict FADCoenzyme A disulfide reductase / 0.759
4gur FADLysine-specific histone demethylase 1B 1 0.759
1cl0 FADThioredoxin reductase 1.8.1.9 0.757
5buk FADFADH2-dependent halogenase / 0.756
4ntd FADThioredoxin reductase / 0.754
2wow FADTrypanothione reductase / 0.753
4gus FADLysine-specific histone demethylase 1B 1 0.753
2bab FADPutative aminooxidase / 0.751
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.751
1fec FADTrypanothione reductase 1.8.1.12 0.750
4jn9 FADDepH / 0.750
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.749
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.746
1tyt FADTrypanothione reductase 1.8.1.12 0.746
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.746
2tpr FADTrypanothione reductase 1.8.1.12 0.746
2b9x FADPutative aminooxidase / 0.743
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.742
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.742
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.741
4cnk FADL-amino acid oxidase / 0.741
2b9y FADPutative aminooxidase / 0.740
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.740
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.737
2cvj FADThioredoxin reductase related protein / 0.736
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.736
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.735
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.735
2wp5 FADTrypanothione reductase / 0.734
3cgb FADCoenzyme A disulfide reductase / 0.734
3cgd FADCoenzyme A disulfide reductase / 0.734
4j57 FADThioredoxin reductase 2 1.8.1.9 0.734
3icr FADCoenzyme A disulfide reductase / 0.733
3cgc FADCoenzyme A disulfide reductase / 0.731
3lad FADDihydrolipoyl dehydrogenase / 0.731
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.730
2gew FADCholesterol oxidase 1.1.3.6 0.729
2igo FADPyranose 2-oxidase / 0.729
2eq7 FADDihydrolipoyl dehydrogenase / 0.728
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.728
2b9w FADPutative aminooxidase / 0.727
4fwj FADLysine-specific histone demethylase 1B 1 0.727
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.726
1joa FADNADH peroxidase 1.11.1.1 0.724
2jk6 FADTrypanothione reductase / 0.724
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.723
2eq6 FADDihydrolipoyl dehydrogenase / 0.723
4u2s FDACholesterol oxidase 1.1.3.6 0.723
3cnj FADCholesterol oxidase 1.1.3.6 0.722
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.720
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.720
2w0h FADTrypanothione reductase / 0.719
3gyi FADCholesterol oxidase 1.1.3.6 0.719
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.718
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.718
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.718
2hqm FADGlutathione reductase 1.8.1.7 0.717
4b1b FADThioredoxin reductase 1.8.1.9 0.717
2eq9 FADDihydrolipoyl dehydrogenase / 0.716
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.716
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.715
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.715
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.715
4fwf FADLysine-specific histone demethylase 1B 1 0.715
1fea FADTrypanothione reductase 1.8.1.12 0.714
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.714
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.713
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.713
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.712
1z6l FADPolyamine oxidase FMS1 / 0.712
5j60 FADThioredoxin reductase / 0.712
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.711
3lsi FADPyranose 2-oxidase / 0.711
4opt FDAConserved Archaeal protein / 0.711
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.709
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.709
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.709
4jq9 FADDihydrolipoyl dehydrogenase / 0.709
4u2t FADCholesterol oxidase 1.1.3.6 0.709
1ges FADGlutathione reductase 1.8.1.7 0.708
4dsh FDAUncharacterized protein / 0.708
2ign FADPyranose 2-oxidase / 0.707
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.707
1geu FADGlutathione reductase 1.8.1.7 0.706
2h94 FADLysine-specific histone demethylase 1A 1 0.706
2zbw FADFerredoxin--NADP reductase / 0.706
3k4c FADPyranose 2-oxidase / 0.706
2eq8 FADDihydrolipoyl dehydrogenase / 0.705
3pl8 FADPyranose 2-oxidase / 0.705
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.705
1n4u FAECholesterol oxidase 1.1.3.6 0.703
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.703
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.702
2ba9 FADPutative aminooxidase / 0.701
2yg4 FADPutrescine oxidase / 0.701
1npx FADNADH peroxidase 1.11.1.1 0.700
3gyj FADCholesterol oxidase 1.1.3.6 0.700
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.698
2qa1 FADPgaE / 0.698
3cty FADProbable thioredoxin reductase / 0.698
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.697
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.697
1nhr FADNADH peroxidase 1.11.1.1 0.697
1zx9 FADMercuric reductase 1.16.1.1 0.697
2x3n FADProbable FAD-dependent monooxygenase / 0.697
3ada NADSubunit alpha of sarocosine oxidase / 0.697
4cnj FADL-amino acid oxidase / 0.697
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.696
2yg3 FADPutrescine oxidase / 0.696
3bg7 FADPyranose 2-oxidase / 0.696
4x4j FADPutative oxygenase / 0.696
2x8g FADThioredoxin glutathione reductase / 0.695
4dsg FADUncharacterized protein / 0.695
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.695
4rsl FADFructosyl peptide oxidase / 0.695
4dna FADProbable glutathione reductase / 0.694
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.694
4guu FA9Lysine-specific histone demethylase 1B 1 0.694
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.694
4rek FADCholesterol oxidase 1.1.3.6 0.694
2rab FADGlutathione amide reductase / 0.691
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.691
4j56 FADThioredoxin reductase 2 1.8.1.9 0.691
4mok FADPyranose 2-oxidase / 0.691
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.690
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.690
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.690
4opi FDAConserved Archaeal protein / 0.690
2gr3 FADFerredoxin reductase / 0.688
1nhs FADNADH peroxidase 1.11.1.1 0.687
4opl FDAConserved Archaeal protein / 0.687
4yry FADGlutamate synthase, beta subunit / 0.687
1xpq FADPolyamine oxidase FMS1 / 0.686
4ntc FADThioredoxin reductase gliT / 0.686
4qi5 FADCellobiose dehydrogenase / 0.686
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.686
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.685
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.685
1cbo FADCholesterol oxidase 1.1.3.6 0.684
1nhq FADNADH peroxidase 1.11.1.1 0.684
3atq FDAConserved Archaeal protein / 0.684
2gqw FADFerredoxin reductase / 0.683
3atr FDAConserved Archaeal protein / 0.683
4em3 FADCoenzyme A disulfide reductase / 0.683
4mih FADPyranose 2-oxidase 1.1.3.10 0.683
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.682
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.682
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
5dbj FADFADH2-dependent halogenase PltA / 0.682
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.681
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.680
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.680
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.680
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.679
4xwr FADCholesterol oxidase 1.1.3.6 0.679
1cf3 FADGlucose oxidase 1.1.3.4 0.678
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.678
4opg FDAConserved Archaeal protein / 0.678
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.677
3cox FADCholesterol oxidase 1.1.3.6 0.677
3k4n FADPyranose 2-oxidase / 0.677
4i58 FADCyclohexylamine Oxidase / 0.677
4u2l SFDCholesterol oxidase 1.1.3.6 0.677
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.676
2bac FADPutative aminooxidase / 0.676
4usq FADPyridine nucleotide-disulfide oxidoreductase / 0.676
1gxf FADTrypanothione reductase 1.8.1.12 0.675
2a87 FADThioredoxin reductase 1.8.1.9 0.675
2yg7 FADPutrescine oxidase / 0.675
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.675
1b8s FADCholesterol oxidase 1.1.3.6 0.674
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.674
3b6d FAECholesterol oxidase 1.1.3.6 0.674
3qvp FADGlucose oxidase 1.1.3.4 0.674
4opu FDAConserved Archaeal protein / 0.674
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.674
4gdp FADPolyamine oxidase FMS1 / 0.673
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.672
2xdo FADTetX family tetracycline inactivation enzyme / 0.672
4k2x FADPolyketide oxygenase/hydroxylase / 0.672
2x8h FADThioredoxin glutathione reductase / 0.671
2yqu FADDihydrolipoyl dehydrogenase / 0.671
4j34 FADKynurenine 3-monooxygenase / 0.671
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.671
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.670
1n4w FADCholesterol oxidase 1.1.3.6 0.670
3v76 FDAUncharacterized protein / 0.669
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.668
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
1ojt FADDihydrolipoyl dehydrogenase / 0.668
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.668
2yg5 FADPutrescine oxidase / 0.668
2yg6 FADPutrescine oxidase / 0.668
3kpf FADPolyamine oxidase 1.5.3.14 0.668
2hko FADLysine-specific histone demethylase 1A 1 0.667
3lsm SFDPyranose 2-oxidase / 0.667
4hb9 FADUncharacterized protein / 0.667
4la1 FADThioredoxin glutathione reductase / 0.667
3bi5 FADPolyamine oxidase FMS1 / 0.666
1d7y FADFerredoxin reductase / 0.665
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
2cul FADGidA-related protein / 0.664
2yvf FADFerredoxin reductase / 0.664
3qj4 FADRenalase / 0.664
3t37 FADPyridoxine 4-oxidase / 0.664
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.664
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.663
1mxt FAECholesterol oxidase 1.1.3.6 0.663
1n1p FADCholesterol oxidase 1.1.3.6 0.663
3ics FADCoenzyme A disulfide reductase / 0.663
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.663
3qvr FADGlucose oxidase 1.1.3.4 0.663
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.663
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.663
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.663
1cc2 FADCholesterol oxidase 1.1.3.6 0.662
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.662
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.662
4ynt FDAGlucose oxidase, putative / 0.662
2cdu FADNADH oxidase / 0.661
2jb2 FADL-amino acid oxidase / 0.661
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.661
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.660
2gr0 FADFerredoxin reductase / 0.659
2v6o FADThioredoxin glutathione reductase / 0.659
4qi4 FADCellobiose dehydrogenase / 0.659
1f3p FADFerredoxin reductase / 0.658
4em4 FADCoenzyme A disulfide reductase / 0.657
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.657
1b4v FADCholesterol oxidase 1.1.3.6 0.656
2gqf FADUncharacterized protein HI_0933 / 0.656
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.656
4fk1 FADPutative thioredoxin reductase / 0.656
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.656
4wuj FMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy / 0.656
2jae FADL-amino acid oxidase / 0.655
3axb FADPutative oxidoreductase / 0.655
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.654
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.654
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.653
1yy5 FADPolyamine oxidase FMS1 / 0.653
2pdt FADVivid PAS protein VVD / 0.653
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.652
2y48 FADLysine-specific histone demethylase 1A 1 0.652
3sz0 FADSulfide-quinone reductase / 0.652
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.652
4wct FADFructosyl amine:oxygen oxidoreductase / 0.652
1n4v FADCholesterol oxidase 1.1.3.6 0.651
1qo8 FADFumarate reductase flavoprotein subunit / 0.651
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.651
4xxg FADCholesterol oxidase 1.1.3.6 0.651
1ng3 FADGlycine oxidase 1.4.3.19 0.650
3ept FDAPutative FAD-monooxygenase / 0.650
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.650
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.650