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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4cbq NDP Thioredoxin reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4cbq NDPThioredoxin reductase / 1.006
4a5l NDPThioredoxin reductase / 0.818
2q0l NAPThioredoxin reductase 1.8.1.9 0.814
4ccq NAPThioredoxin reductase / 0.798
3lzx NAPFerredoxin--NADP reductase 2 1.18.1.2 0.788
4gcm NAPThioredoxin reductase 1.8.1.9 0.772
3lzw NAPFerredoxin--NADP reductase 2 1.18.1.2 0.740
4up3 NDPThioredoxin reductase / 0.718
4b65 NDPL-ornithine N(5)-monooxygenase / 0.706
3gwf NAPCyclohexanone monooxygenase / 0.690
2xlt NA0Putative flavin-containing monooxygenase / 0.684
4b64 NAPL-ornithine N(5)-monooxygenase / 0.680
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.676
4b68 NAPL-ornithine N(5)-monooxygenase / 0.672
4ovi N01Phenylacetone monooxygenase 1.14.13.92 0.672
5cku NAPL-ornithine N(5)-monooxygenase / 0.670
4e5o UMPThymidylate synthase 2.1.1.45 0.659
3s5w NAPL-ornithine N(5)-monooxygenase / 0.656
1hdo NAPFlavin reductase (NADPH) / 0.654
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.651