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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c8b 0LI Receptor-interacting serine/threonine-protein kinase 2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 1.209
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.869
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.861
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.852
4qrc 0LIFibroblast growth factor receptor 4 2.7.10.1 0.801
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.776
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.748
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.731
3ugc 046Tyrosine-protein kinase JAK2 / 0.720
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.712
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.711
3b8q 900Vascular endothelial growth factor receptor 2 2.7.10.1 0.706
3s4q NK0Mitogen-activated protein kinase 14 / 0.703
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.685
4kip 1R9Mitogen-activated protein kinase 14 / 0.682
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.677
2yis YISMitogen-activated protein kinase 14 / 0.674
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.668
3mvl 38PMitogen-activated protein kinase 14 / 0.667
4o2z 046Mitogen-activated protein kinase / 0.666
3b2w 9NHTyrosine-protein kinase Lck 2.7.10.2 0.665
3nnw EDDMitogen-activated protein kinase 14 / 0.663
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.661
3hv7 1AUMitogen-activated protein kinase 14 / 0.661
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.658
3hv4 L51Mitogen-activated protein kinase 14 / 0.658
3itz P66Mitogen-activated protein kinase 14 / 0.658
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.655
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.654
3gi3 B10Mitogen-activated protein kinase 14 / 0.654
3hv6 R39Mitogen-activated protein kinase 14 / 0.654
2zb1 GK4Mitogen-activated protein kinase 14 / 0.651