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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c7k NAP Corticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 1.417
3g49 NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 1.041
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 1.001
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.981
3o4r NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.887
1x7h NDPPutative ketoacyl reductase 1.3.1 0.879
1oaa NAPSepiapterin reductase 1.1.1.153 0.868
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.867
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.852
3uce NDPDehydrogenase / 0.836
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.836
3ai2 NDPNADPH-sorbose reductase / 0.835
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.825
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.823
1x7g NAPPutative ketoacyl reductase 1.3.1 0.822
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.820
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.820
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.818
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.812
2wdz NADGalactitol dehydrogenase / 0.811
4j7u NAPSepiapterin reductase 1.1.1.153 0.810
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.808
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.807
1ae1 NAPTropinone reductase 1 / 0.804
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.801
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.801
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.796
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.795
3u4c NDPNADPH-dependent reductase BacG / 0.791
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.788
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.784
4kwh NAPReductase homolog / 0.784
2dte NAIGlucose 1-dehydrogenase related protein / 0.783
3ai3 NDPNADPH-sorbose reductase / 0.782
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.782
4wec NADShort chain dehydrogenase / 0.776
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.774
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.773
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.773
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.773
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.771
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.770
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.769
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.768
5jyd NADShort chain dehydrogenase / 0.768
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.767
4b79 NADProbable short-chain dehydrogenase / 0.766
5lc1 NADL-threonine 3-dehydrogenase / 0.766
2hrb NAPCarbonyl reductase [NADPH] 3 1.1.1.184 0.765
4hwk NAPSepiapterin reductase 1.1.1.153 0.763
3geg NADShort-chain dehydrogenase/reductase SDR / 0.761
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.761
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.760
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.760
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.760
3p19 NDPPutative blue fluorescent protein / 0.760
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.758
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.757
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.756
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.755
3d3w NAPL-xylulose reductase 1.1.1.10 0.755
5d2e NAPMlnE / 0.754
4u7w NDPMxaA / 0.753
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.750
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.750
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.749
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.746
4idg NADPutative UDP-glucose 4-epimerase / 0.742
2yut NAPPutative short-chain oxidoreductase / 0.740
3qrw NDPPutative ketoacyl reductase 1.3.1 0.740
2yy7 NADL-threonine dehydrogenase / 0.739
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.739
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.738
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.738
3tsc NADUncharacterized protein / 0.738
1g6k NADGlucose 1-dehydrogenase 1.1.1.47 0.737
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.737
1sny NAPLD36273p / 0.736
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.735
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.735
3ak4 NADNADH-dependent quinuclidinone reductase / 0.734
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.733
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.733
4dbz NDPPutative ketoacyl reductase 1.3.1 0.733
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.731
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.730
4j7x NAPSepiapterin reductase 1.1.1.153 0.730
2ydx NAPMethionine adenosyltransferase 2 subunit beta / 0.729
2c29 NAPDihydroflavonol 4-reductase / 0.728
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.727
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.726
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.724
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.723
3wmx NADNAD dependent epimerase/dehydratase / 0.721
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.720
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.720
3r3s NADPutative oxidoreductase / 0.720
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.719
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.718
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.717
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.715
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.715
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.714
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.711
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.711
4yr9 NADL-threonine 3-dehydrogenase, mitochondrial 1.1.1.103 0.711
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.710
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.710
4nbw NADShort-chain dehydrogenase/reductase SDR / 0.709
1g1a NADdTDP-glucose 4,6-dehydratase / 0.708
3lqf NADGalactitol dehydrogenase / 0.708
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.707
3s55 NADPutative short-chain dehydrogenase/reductase / 0.706
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.706
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.705
2gn8 NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.705
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.704
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.704
1e7y NDPGlucose-6-phosphate 1-dehydrogenase / 0.703
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.703
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.703
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.703
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.701
1xkq NDPUncharacterized protein / 0.701
3wds NADNADH-dependent quinuclidinone reductase / 0.701
5jla NADPutative short-chain dehydrogenase/reductase / 0.701
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.700
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.700
3mje NDPAmphB / 0.700
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.700
3bmo NAPPteridine reductase / 0.699
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.698
2wsb NADGalactitol dehydrogenase / 0.697
3aw9 NADNAD-dependent epimerase/dehydratase / 0.697
4clo NAPPteridine reductase / 0.697
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.697
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.696
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.695
3h2s NDPPutative NADH-flavin reductase / 0.695
3o26 NDPSalutaridine reductase / 0.695
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.693
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.693
4b8w NAPGDP-L-fucose synthase 1.1.1.271 0.693
4l4x NDPAmphI / 0.693
4fw8 NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.692
4qed NAPElxO / 0.692
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.690
2pzj NADPutative nucleotide sugar epimerase/ dehydratase / 0.689
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.689
4bkq NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.689
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.688
1w4z NAPPutative ketoacyl reductase 1.3.1 0.687
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.687
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.687
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.686
3orf NADDihydropteridine reductase 1.5.1.34 0.686
3sx2 NADUncharacterized protein / 0.686
4fn4 NADShort chain dehydrogenase / 0.686
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.685
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.685
1i3l NADUDP-glucose 4-epimerase / 0.684
3f1k NAPUncharacterized oxidoreductase YciK 1 0.684
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.684
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.683
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.683
4ocg COAFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.683
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.682
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.682
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.679
3a9w NADNDP-sugar epimerase / 0.679
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.679
2bd0 NAPSepiapterin reductase / 0.677
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.676
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.676
2yjz NAPMetalloreductase STEAP4 1.16.1 0.675
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.674
1ipe NDPTropinone reductase 2 1.1.1.236 0.673
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.673
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.673
5j23 A2RPutative 2-hydroxyacid dehydrogenase / 0.673
3l77 NJPShort-chain alcohol dehydrogenase / 0.672
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.671
4hxy NDPPlm1 / 0.671
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.670
2bfo NDPPteridine reductase 1 1.5.1.33 0.670
4bmv NAPShort-chain dehydrogenase / 0.670
1wnt NAPL-xylulose reductase 1.1.1.10 0.669
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.669
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.668
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.668
1fxs NAPGDP-L-fucose synthase / 0.667
1qyv NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.666
1rpn NDPGDP-mannose 4,6-dehydratase / 0.666
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.666
4fj1 NAP17beta-hydroxysteroid dehydrogenase / 0.665
4qec NAPElxO / 0.665
3i6i NDPPutative leucoanthocyanidin reductase 1 / 0.664
4id9 NADPutative UDP-glucose 4-epimerase / 0.664
5b1y NDP3-oxoacyl-[acyl-carrier-protein] reductase / 0.664
1ahh NAD7-alpha-hydroxysteroid dehydrogenase 1.1.1.159 0.663
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.663
3tn7 NJPShort-chain alcohol dehydrogenase / 0.662
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.662
1kc1 NDPdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.661
4hc4 SAHProtein arginine N-methyltransferase 6 / 0.661
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.660
4twr NADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase / 0.660
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.659
1pr9 NAPL-xylulose reductase 1.1.1.10 0.659
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.658
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.658
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.658
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.658
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.658
2p5u NADUDP-glucose 4-epimerase / 0.656
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.655
3h4v NAPPteridine reductase 1 1.5.1.33 0.655
4eue NAITrans-2-enoyl-CoA reductase [NADH] / 0.655
4lk3 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.655
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.654
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.654
1vrw NAIEnoyl-ACP reductase / 0.653
4o1m NADEnoyl-acyl carrier reductase / 0.653
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.653
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.652
1bws NDPGDP-L-fucose synthase / 0.652
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.652
4hbg NDP3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.652
3a4v NADNDP-sugar epimerase / 0.651
1hdo NAPFlavin reductase (NADPH) / 0.650