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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c3p ACP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c3p ACPAurora kinase A 2.7.11.1 0.916
4c3r ACPAurora kinase A 2.7.11.1 0.771
2wqe ADPAurora kinase A 2.7.11.1 0.705
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.700
3c4w ATPRhodopsin kinase / 0.693
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.690
3bu5 ATPInsulin receptor 2.7.10.1 0.686
4n57 ADPAPH(2'')-Id / 0.684
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.683
3ori AGSSerine/threonine protein kinase / 0.680
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.677
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.676
5dt4 ATPAurora kinase A 2.7.11.1 0.676
5l8l ADPAurora kinase A 2.7.11.1 0.676
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.675
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.671
3orm AGSSerine/threonine protein kinase / 0.666
4q5h ANPProtein kinase OspG 2.7 0.665
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.664
4ysj ADPCalmodulin-like domain protein kinase / 0.664
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.663
4dee ADPAurora kinase A 2.7.11.1 0.663
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.662
5dt3 ATPAurora kinase A 2.7.11.1 0.662
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.661
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.660
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.660
4xlv ACPInsulin receptor 2.7.10.1 0.660
5dos ATPAurora kinase A 2.7.11.1 0.660
5jqw ADPN5-carboxyaminoimidazole ribonucleotide synthase / 0.660
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.659
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.659
2pun ACPMethylthioribose kinase 2.7.1.100 0.658
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.658
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.658
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.658
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.657
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.656
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.655
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.653
3i7v B4PAP4A hydrolase / 0.652
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.652
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.651
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.651
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.650
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.650